{"id":"amlodipine-folic-acid-placebos","safety":{"commonSideEffects":[{"rate":"5-10%","effect":"Peripheral edema"},{"rate":"5-7%","effect":"Headache"},{"rate":"3-5%","effect":"Flushing"},{"rate":"2-4%","effect":"Fatigue"},{"rate":"2-3%","effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1200402","moleculeType":"Small molecule","molecularWeight":"567.06"},"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Amlodipine-folic acid placebos","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T04:29:49.183640+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T04:29:54.093171+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Amlodipine-folic acid placebos","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T04:29:54.292844+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Voltage-gated L-type calcium channel blocker","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T04:29:56.119066+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200402/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T04:29:55.727708+00:00"}},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reduced peripheral vascular resistance. Folic acid (vitamin B9) is included as a supplementary component to support homocysteine metabolism and reduce cardiovascular risk. This combination product targets hypertension management with adjunctive nutritional support.","oneSentence":"Amlodipine blocks L-type calcium channels to reduce blood pressure, while folic acid supplementation supports cardiovascular and metabolic health.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:27:02.664Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T04:29:57.335465+00:00","fieldsConflicting":0,"overallConfidence":0.95},"indications":{"approved":[{"name":"Hypertension"},{"name":"Angina pectoris"}]},"trialDetails":[{"nctId":"NCT04974138","phase":"PHASE4","title":"China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT)","status":"RECRUITING","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2024-08-22","conditions":"Hypertension, MTHFR 677 CC or CT Genotype, Elevated Plasma Homocysteine (Hcy≥10µmol/L)","enrollment":32000},{"nctId":"NCT04974151","phase":"PHASE4","title":"China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype","status":"RECRUITING","sponsor":"Shenzhen Ausa Pharmed Co.,Ltd","startDate":"2024-08-22","conditions":"Hypertension, MTHFR 677 TT Genotype","enrollment":24000}],"_emaApprovals":[],"_faersSignals":[],"crossReferences":{"chemblId":"CHEMBL1200402"},"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Amlodipine-folic acid (dummy)"],"phase":"marketed","status":"active","brandName":"Amlodipine-folic acid placebos","genericName":"Amlodipine-folic acid placebos","companyName":"Shenzhen Ausa Pharmed Co.,Ltd","companyId":"shenzhen-ausa-pharmed-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amlodipine blocks L-type calcium channels to reduce blood pressure, while folic acid supplementation supports cardiovascular and metabolic health. Used for Hypertension, Angina pectoris.","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T04:29:57.335465+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}