{"id":"amitriptyline-plus-fluoxitine","safety":{"commonSideEffects":[{"rate":null,"effect":"Serotonin syndrome"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1200964","moleculeType":"Small molecule","molecularWeight":"313.87"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Amitriptyline is a tricyclic antidepressant that inhibits reuptake of both serotonin and norepinephrine at the neuronal synapse. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that specifically blocks serotonin reuptake. Together, they create a synergistic increase in synaptic serotonin concentration, potentially enhancing antidepressant and anxiolytic effects. However, this combination is not standard clinical practice and carries increased risk of serotonin syndrome.","oneSentence":"This combination increases serotonin availability in the brain through dual mechanisms: amitriptyline blocks serotonin and norepinephrine reuptake, while fluoxetine selectively inhibits serotonin reuptake.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:27:01.705Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Depression (off-label or investigational combination)"},{"name":"Anxiety disorders (off-label or investigational combination)"}]},"trialDetails":[{"nctId":"NCT00000428","phase":"PHASE4","title":"Combining N-of-1 Trials to Assess Fibromyalgia Treatments","status":"COMPLETED","sponsor":"Tufts Medical Center","startDate":"2000-09","conditions":"Fibromyalgia","enrollment":58}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["elavil plus prozac"],"phase":"marketed","status":"active","brandName":"Amitriptyline plus Fluoxitine","genericName":"Amitriptyline plus Fluoxitine","companyName":"Tufts Medical Center","companyId":"tufts-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination increases serotonin availability in the brain through dual mechanisms: amitriptyline blocks serotonin and norepinephrine reuptake, while fluoxetine selectively inhibits serotonin reuptake. Used for Depression (off-label or investigational combination), Anxiety disorders (off-label or investigational combination).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}