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It also has Class I, II, and IV properties due to its effects on sodium, beta-adrenergic, and calcium channels, making it a broad-spectrum antiarrhythmic. This multi-channel blockade makes it effective for suppressing both atrial and ventricular arrhythmias.","oneSentence":"Amiodarone blocks multiple cardiac ion channels (sodium, potassium, calcium, and beta-adrenergic) to slow electrical conduction and suppress abnormal heart rhythms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:01:11.879Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrial fibrillation (maintenance of sinus rhythm and rate control)"},{"name":"Ventricular tachycardia and ventricular fibrillation"},{"name":"Supraventricular tachycardia"},{"name":"Prevention of recurrent atrial fibrillation in patients with structural heart disease"}]},"trialDetails":[{"nctId":"NCT06669299","phase":"NA","title":"Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies","status":"RECRUITING","sponsor":"IRCCS Ospedale San Raffaele","startDate":"2025-06-12","conditions":"Ventricular Tachycardia 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