{"id":"aminoquinuride","rwe":[{"pmid":"35887049","year":"2022","title":"Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"}],"tags":[{"label":"aminoquinuride","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Interstitial collagenase","category":"target"},{"label":"MMP1","category":"gene"},{"label":"MMP9","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"surfen","offLabel":[],"synonyms":["aminoquinuride","aminochinuride","aminokinuride","aminoquincarbamide","surfen"],"timeline":[],"brandName":"Surfen","ecosystem":[],"mechanism":{"target":"Matrix metalloproteinase-9, Interstitial collagenase, Botulinum neurotoxin type A","targets":[{"gene":"MMP1","source":"DrugCentral","target":"Interstitial collagenase","protein":"Interstitial collagenase"},{"gene":"MMP9","source":"DrugCentral","target":"Matrix metalloproteinase-9","protein":"Matrix metalloproteinase-9"}],"modality":"Small Molecule","drugClass":"aminoquinuride","explanation":"Think of collagen like a strong rope that holds things together. When interstitial collagenase is active, it can break down this rope, leading to damage and disease. Surfen helps to stop this breakdown by blocking the action of the enzyme, which can help to prevent or treat conditions where collagen is damaged.","oneSentence":"Surfen works by blocking the action of an enzyme called interstitial collagenase, which breaks down collagen.","technicalDetail":"Surfen exerts its effects through competitive inhibition of interstitial collagenase, a matrix metalloproteinase involved in the degradation of collagen and other extracellular matrix components."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/174","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=AMINOQUINURIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AMINOQUINURIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:41:16.710187","biosimilars":[],"competitors":[{"drugName":"beclometasone dipropionate","drugSlug":"beclometasone-dipropionate","fdaApproval":"1976-05-12","relationship":"same-target"},{"drugName":"budesonide","drugSlug":"budesonide","fdaApproval":"1994-02-14","patentExpiry":"Sep 9, 2036","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"busulfan","drugSlug":"busulfan","fdaApproval":"1954-06-26","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"cefalotin","drugSlug":"cefalotin","fdaApproval":"1974-12-18","relationship":"same-target"},{"drugName":"cefonicid","drugSlug":"cefonicid","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"cefotetan","drugSlug":"cefotetan","fdaApproval":"1985-12-27","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"cefotiam","drugSlug":"cefotiam","fdaApproval":"","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"cefradine","drugSlug":"cefradine","fdaApproval":"1974-08-19","relationship":"same-target"},{"drugName":"cefuroxime","drugSlug":"cefuroxime","fdaApproval":"1983-10-19","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"aminoquinuride","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"beclometasone-dipropionate","brandName":"beclometasone dipropionate","genericName":"beclometasone dipropionate","approvalYear":"1976","relationship":"same-target"},{"drugId":"budesonide","brandName":"budesonide","genericName":"budesonide","approvalYear":"1994","relationship":"same-target"},{"drugId":"busulfan","brandName":"busulfan","genericName":"busulfan","approvalYear":"1954","relationship":"same-target"},{"drugId":"cefalotin","brandName":"cefalotin","genericName":"cefalotin","approvalYear":"1974","relationship":"same-target"},{"drugId":"cefonicid","brandName":"cefonicid","genericName":"cefonicid","approvalYear":"","relationship":"same-target"},{"drugId":"cefotetan","brandName":"cefotetan","genericName":"cefotetan","approvalYear":"1985","relationship":"same-target"},{"drugId":"cefotiam","brandName":"cefotiam","genericName":"cefotiam","approvalYear":"","relationship":"same-target"},{"drugId":"cefradine","brandName":"cefradine","genericName":"cefradine","approvalYear":"1974","relationship":"same-target"},{"drugId":"cefuroxime","brandName":"cefuroxime","genericName":"cefuroxime","approvalYear":"1983","relationship":"same-target"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT04362384","phase":"PHASE3","title":"Topical Vitamin E Ovules for the Treatment of Hemorrhoids","status":"UNKNOWN","sponsor":"Hospital General Universitario Elche","startDate":"2020-05-01","conditions":["Bleeding Anal","Pain","Stings"],"enrollment":120,"completionDate":"2020-10-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"006338","UNII":"08T7936572","INN_ID":"63","RXNORM":"17747","UMLSCUI":"C0051675","ChEMBL_ID":"CHEMBL87223","DRUGBANK_ID":"DB04452","PDB_CHEM_ID":"NSC","PUBCHEM_CID":"71166","MESH_SUPPLEMENTAL_RECORD_UI":"C010850"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2022 Jul 12","pmid":"35887049","title":"Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase.","journal":"International journal of molecular sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Surfen is a small molecule with the synonyms AMINOCHINURIDE, AMINOQUINURIDA, and AMINOQUINURIDE. It has been studied in clinical trials for the treatment of hemorrhoids, anal pain, and stings, using topical vitamin E ovules and prednisolone ointment as interventions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}