{"id":"aminomethylbenzoic-acid","rwe":[],"tags":[{"label":"aminomethylbenzoic acid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B02AA03","category":"atc"},{"label":"Active","category":"status"},{"label":"Antifibrinolytic Agents","category":"pharmacology"},{"label":"Coagulants","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Hemostatics","category":"pharmacology"},{"label":"Protease Inhibitors","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:32:33.601910","allNames":"gumbix","offLabel":[],"synonyms":["p-aminomethylbenzoic acid","para-aminomethylbenzoic acid","gumbix","4-aminomethyl-benzoic acid","4-aminomethylbenzoic acid","aminomethylbenzoic acid","benzylamine-4-carboxylic acid","p-carboxybenzylamine"],"timeline":[],"brandName":"Gumbix","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"aminomethylbenzoic acid","explanation":"Imagine your body's cells have locks on them, and Gumbix is a key that fits into one of those locks. When it binds to the lock, it triggers a series of events that help to treat a particular disease or condition. This is a simplified explanation of how Gumbix works at a molecular level.","oneSentence":"Gumbix works by interacting with a specific molecular target to produce a therapeutic effect.","technicalDetail":"Gumbix is a competitive inhibitor of a specific enzyme or receptor, which leads to a decrease in the production of a downstream molecule involved in disease pathology."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/22","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=aminomethylbenzoic%20acid","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=aminomethylbenzoic acid","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:43:12.348337","biosimilars":[],"competitors":[{"drugName":"aminocaproic acid","drugSlug":"aminocaproic-acid","fdaApproval":"1964-06-03","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"tranexamic acid","drugSlug":"tranexamic-acid","fdaApproval":"1986-12-30","genericCount":26,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"aminomethylbenzoic acid","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(102)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"aminocaproic-acid","brandName":"aminocaproic acid","genericName":"aminocaproic acid","approvalYear":"1964","relationship":"same-class"},{"drugId":"tranexamic-acid","brandName":"tranexamic acid","genericName":"tranexamic acid","approvalYear":"1986","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT06418568","phase":"NA","title":"Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of Melasma","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2024-04-01","conditions":["Chloasma"],"enrollment":60,"completionDate":"2024-12-30"},{"nctId":"NCT01828892","phase":"NA","title":"Glue Application in the Treatment of Low-Output Fistulas","status":"UNKNOWN","sponsor":"Jinling Hospital, China","startDate":"2014-03","conditions":["Low-output External Gastrointestinal Fistula"],"enrollment":30,"completionDate":"2017-12"},{"nctId":"NCT01672593","phase":"NA","title":"Glue Sealing for Patients With Low-Output ECFs","status":"UNKNOWN","sponsor":"Jinling Hospital, China","startDate":"2012-05","conditions":["Low-output External Gastrointestinal Fistula"],"enrollment":30,"completionDate":"2014-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007158","UNII":"68WG9JKC7L","CHEBI":"CHEBI:134774","RXNORM":"14852","UMLSCUI":"C0048045","ChEMBL_ID":"CHEMBL328875","KEGG_DRUG":"D07568","DRUGBANK_ID":"DB13244","PDB_CHEM_ID":"4AZ","PUBCHEM_CID":"65526","MESH_SUPPLEMENTAL_RECORD_UI":"C015668"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":102,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"B02AA03","allCodes":["B02AA03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 2","pmid":"41526307","title":"Synergistic Blend of p-Aminomethylbenzoic Acid in Electrohydrodynamically Atomized Chitosan-PVA Composite Particles for Hemostasis and Wound Healing.","journal":"ACS applied bio materials"},{"date":"2024 Aug 7","pmid":"39011606","title":"Effect of the Hammett substituent constant of para-substituted benzoic acid on the perovskite/SnO(2) interface passivation in perovskite solar cells.","journal":"Nanoscale"},{"date":"2023 Mar 13","pmid":"36912744","title":"Medical interventions for traumatic hyphema.","journal":"The Cochrane database of systematic reviews"},{"date":"2022 Jul 22","pmid":"35866832","title":"Hyperfibrinolysis secondary to acquired factor XIII deficiency A case report.","journal":"Medicine"},{"date":"2022 Jul","pmid":"35305164","title":"Furanonyl amino acid derivatives as hemostatic drugs: design, synthesis and hemostasis performance.","journal":"Amino acids"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Gumbix is an antifibrinolytic agent. Its exact mechanism of action is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}