{"id":"aminolevulinic-acid-ala","safety":{"commonSideEffects":[{"rate":null,"effect":"Photosensitivity/skin phototoxicity"},{"rate":null,"effect":"Burning or stinging at treatment site"},{"rate":null,"effect":"Erythema and edema"},{"rate":null,"effect":"Post-inflammatory hyperpigmentation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"ALA is converted intracellularly to protoporphyrin IX (PpIX), a photosensitizer that accumulates preferentially in rapidly dividing and abnormal cells. Upon exposure to specific wavelengths of light, PpIX generates singlet oxygen and other reactive oxygen species that cause direct cell death and vascular damage, making it useful for both diagnostic fluorescence imaging and therapeutic photodynamic therapy.","oneSentence":"Aminolevulinic acid is a precursor to protoporphyrin IX, which accumulates in cells and generates reactive oxygen species when activated by light, enabling photodynamic therapy.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:17.711Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis (photodynamic therapy)"},{"name":"Non-melanoma skin cancer (photodynamic therapy)"},{"name":"Glioblastoma (intraoperative fluorescence-guided surgery)"}]},"trialDetails":[{"nctId":"NCT06876038","phase":"PHASE2","title":"Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions","status":"NOT_YET_RECRUITING","sponsor":"University of Massachusetts, Boston","startDate":"2026-09","conditions":"Oral Cancer, Oral Cavity Cancer, Oral Leukoplakia","enrollment":65},{"nctId":"NCT07225621","phase":"PHASE2","title":"Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma","status":"RECRUITING","sponsor":"Alpheus Medical, Inc.","startDate":"2026-01-28","conditions":"Glioblastoma, GBM","enrollment":103},{"nctId":"NCT07241585","phase":"NA","title":"Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT)","status":"NOT_YET_RECRUITING","sponsor":"Case Comprehensive Cancer Center","startDate":"2026-05-01","conditions":"Nonmelanoma Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma","enrollment":54},{"nctId":"NCT06417281","phase":"PHASE3","title":"Photodynamic Diagnosis for Malignant Brain Glioma With 5-Aminolevulinic Acid（5-ALA）","status":"COMPLETED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2024-06-19","conditions":"5-aminolevulinic Acid, Malignant Glioma of Brain","enrollment":86},{"nctId":"NCT07144345","phase":"PHASE3","title":"Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2025-11-19","conditions":"Actinic Keratosis","enrollment":160},{"nctId":"NCT06665724","phase":"PHASE1","title":"Clinical Trial Evaluating Safety of 5-Aminolevulinic Acid (5-ALA) Combined With CV01 Delivery of Ultrasound for Sonodynamic Therapy (SDT) in Patients With Newly Diagnosed High-Grade Glioma (HGG) Prior to Resection and Standard Adjuvant Therapy (ALA SDT GLIOMA 401)","status":"COMPLETED","sponsor":"Universität Münster","startDate":"2025-01-27","conditions":"Anaplastic Astrocytoma (AA), Anaplastic Oligodendroglioma (AO), Glioblastoma (GBM)","enrollment":16},{"nctId":"NCT07038278","phase":"EARLY_PHASE1","title":"5-AminoLevulinic Acid Aided Resection Margins in Sarcoma","status":"NOT_YET_RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2026-04-01","conditions":"Soft Tissue Sarcoma (STS)","enrollment":20},{"nctId":"NCT07076472","phase":"EARLY_PHASE1","title":"Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2025-08-14","conditions":"Progressive Glioblastoma, Recurrent Glioblastoma","enrollment":8},{"nctId":"NCT07144852","phase":"PHASE3","title":"Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2025-11-29","conditions":"Actinic Keratosis","enrollment":260},{"nctId":"NCT05923060","phase":"PHASE2","title":"Imaging Techniques to Monitor Photosensitizer and sO2 Levels During Photodynamic Therapy of Actinic Keratoses","status":"COMPLETED","sponsor":"Case Comprehensive Cancer Center","startDate":"2024-08-25","conditions":"Actinic Keratoses","enrollment":14},{"nctId":"NCT07420543","phase":"","title":"Clinical Significance of Liquid Biopsy in Brain Tumor Patients: a 5-ALA Guided Approach","status":"RECRUITING","sponsor":"Fondazione I.R.C.C.S. 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