{"id":"aminolaevulinic-acid-photodynamic-therapy","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin photosensitivity"},{"rate":"null","effect":"Skin rash"}]},"_chembl":{"chemblId":"CHEMBL483886","moleculeType":"Small molecule","molecularWeight":"258.27"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"This mechanism is based on the principle of photodynamic therapy, where a photosensitizer is activated by light to produce reactive oxygen species, leading to cell death.","oneSentence":"Aminolaevulinic acid acts as a precursor to porphyrin, which accumulates in cancer cells and is activated by light to produce reactive oxygen species, inducing cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:08:50.590Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis"},{"name":"Basal cell carcinoma"}]},"trialDetails":[{"nctId":"NCT06307548","phase":"PHASE1, PHASE2","title":"Fluorescence Image 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Lesions","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2011-05","conditions":"Leukoplakia, Lichen","enrollment":28},{"nctId":"NCT01148966","phase":"PHASE1","title":"Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors","status":"TERMINATED","sponsor":"University of Washington","startDate":"2010-06","conditions":"Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma","enrollment":6},{"nctId":"NCT02520700","phase":"NA","title":"A Comparison of White-light and Daylight Topical Methyl 5-aminolaevulinic Acid Photodynamic Therapy for Actinic Keratoses","status":"COMPLETED","sponsor":"St Vincent's University Hospital, Ireland","startDate":"2013-09","conditions":"Actinic Keratoses","enrollment":22},{"nctId":"NCT01697670","phase":"PHASE1","title":"Photodynamic Therapy for Ulcerative Colitis","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2012-09","conditions":"Ulcerative Colitis","enrollment":7},{"nctId":"NCT01245946","phase":"PHASE2","title":"Photodynamic Therapy Compared to Adapalene 0.1% Gel Plus Doxycycline in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2010-10","conditions":"Acne","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":88,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Aminolaevulinic acid photodynamic therapy","genericName":"Aminolaevulinic acid photodynamic therapy","companyName":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","companyId":"shanghai-fudan-zhangjiang-bio-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aminolaevulinic acid acts as a precursor to porphyrin, which accumulates in cancer cells and is activated by light to produce reactive oxygen species, inducing cell death. Used for Actinic keratosis, Basal cell carcinoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}