{"id":"aminolaevulinic-acid","safety":{"commonSideEffects":[{"rate":"null","effect":"Phototoxicity"},{"rate":"null","effect":"Skin rash"}]},"_chembl":{"chemblId":"CHEMBL483886","moleculeType":"Small molecule","molecularWeight":"258.27"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Aminolaevulinic acid is used in photodynamic therapy to selectively target cancer cells. It is activated by light to produce a photosensitizer that generates reactive oxygen species, leading to cell death.","oneSentence":"Aminolaevulinic acid is a precursor to porphobilinogen, which is involved in the biosynthesis of heme.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:08:44.854Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Actinic keratosis"},{"name":"Basal cell carcinoma"}]},"trialDetails":[{"nctId":"NCT06307548","phase":"PHASE1, PHASE2","title":"Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer","status":"SUSPENDED","sponsor":"Roswell Park Cancer Institute","startDate":"2024-07-30","conditions":"Locally Advanced Colorectal Carcinoma, Recurrent Colorectal Carcinoma, Stage III Colorectal Cancer","enrollment":21},{"nctId":"NCT07366892","phase":"","title":"Leica Microsystems Sponsored PMCF Study to Collect and Confirm Clinical Data on the Performance of the GLOW400 Device When Used in Accordance With Its Intended Use","status":"NOT_YET_RECRUITING","sponsor":"Leica Microsystems (Schweiz) AG","startDate":"2026-02-01","conditions":"Suspected Grade III and IV Gliomas Requiring Surgical Intervention, Neurosurgical Procedure, Glioma","enrollment":37},{"nctId":"NCT06052033","phase":"NA","title":"Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection","status":"RECRUITING","sponsor":"First Affiliated Hospital of Wenzhou Medical University","startDate":"2023-09-11","conditions":"HPV-Related Cervical Carcinoma, Low-Grade Squamous Intraepithelial Lesions, HPV Infection","enrollment":40},{"nctId":"NCT06445699","phase":"NA","title":"Photodynamic Therapy With Hydrogel Dressing for Chronic Wounds","status":"RECRUITING","sponsor":"Army Medical University, China","startDate":"2023-01-01","conditions":"Photodynamic Therapy","enrollment":69},{"nctId":"NCT06439433","phase":"PHASE2","title":"ALA-PDT in Patients With CIN2 in p16-positivity and High-risk HPV Infection","status":"COMPLETED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2021-05-31","conditions":"Cervical Intraepithelial Neoplasia Grade 2, Papillomavirus Infections, p16 Protein","enrollment":119},{"nctId":"NCT00752323","phase":"PHASE2","title":"Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma","status":"COMPLETED","sponsor":"Andrew Sloan, MD","startDate":"2009-12-08","conditions":"Brain and Central Nervous System Tumors","enrollment":73},{"nctId":"NCT02631863","phase":"PHASE2","title":"Aminolaevulinic Acid Photodynamic Therapy for HPV+ Low Grade Cervical Intraepithelial Neoplasia (LSIL;CIN1)","status":"COMPLETED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2016-03-22","conditions":"Cervical Intraepithelial Neoplasia, Low-Grade Squamous Intraepithelial Lesions, Papillomavirus Infections","enrollment":60},{"nctId":"NCT02304770","phase":"PHASE2","title":"Aminolaevulinic Acid Photodynamic Therapy of Cervical Persistent HPV Infection and Cervical Neoplasia","status":"COMPLETED","sponsor":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","startDate":"2015-01","conditions":"Cervical Persistent High Risk HPV Infection, Cervical Intraepithelial Neoplasia","enrollment":73},{"nctId":"NCT01575275","phase":"PHASE2","title":"Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme","status":"TERMINATED","sponsor":"Michael Vogelbaum, MD, PhD","startDate":"2012-05","conditions":"Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma","enrollment":8},{"nctId":"NCT01497951","phase":"PHASE3","title":"Photodynamic Therapy for Oral Precursor Lesions","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2011-05","conditions":"Leukoplakia, Lichen","enrollment":28},{"nctId":"NCT01148966","phase":"PHASE1","title":"Aminolevulinic Acid During Surgery in Treating Patients With Malignant Brain Tumors","status":"TERMINATED","sponsor":"University of Washington","startDate":"2010-06","conditions":"Adult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma","enrollment":6},{"nctId":"NCT02520700","phase":"NA","title":"A Comparison of White-light and Daylight Topical Methyl 5-aminolaevulinic Acid Photodynamic Therapy for Actinic Keratoses","status":"COMPLETED","sponsor":"St Vincent's University Hospital, Ireland","startDate":"2013-09","conditions":"Actinic Keratoses","enrollment":22},{"nctId":"NCT01697670","phase":"PHASE1","title":"Photodynamic Therapy for Ulcerative Colitis","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2012-09","conditions":"Ulcerative Colitis","enrollment":7},{"nctId":"NCT01245946","phase":"PHASE2","title":"Photodynamic Therapy Compared to Adapalene 0.1% Gel Plus Doxycycline in the Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Pontificia Universidad Catolica de Chile","startDate":"2010-10","conditions":"Acne","enrollment":46}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1065,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Aminolaevulinic acid","genericName":"Aminolaevulinic acid","companyName":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","companyId":"shanghai-fudan-zhangjiang-bio-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aminolaevulinic acid is a precursor to porphobilinogen, which is involved in the biosynthesis of heme. Used for Actinic keratosis, Basal cell carcinoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}