{"id":"aminobenzoic-acid","rwe":[],"tags":[{"label":"Vitamin B Complex Member","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Carbonic anhydrase 2","category":"target"},{"label":"CA2","category":"gene"},{"label":"CA1","category":"gene"},{"label":"D02BA01","category":"atc"},{"label":"Active","category":"status"},{"label":"Dermatomyositis","category":"indication"},{"label":"Induratio penis plastica","category":"indication"},{"label":"Morphea","category":"indication"},{"label":"Pemphigus","category":"indication"},{"label":"Systemic sclerosis","category":"indication"}],"phase":"unknown","safety":{"safetySignals":[{"llr":181.486,"date":"","count":40,"signal":"Appendicolith","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=181)"},{"llr":172.244,"date":"","count":91,"signal":"Somnolence","source":"DrugCentral FAERS","actionTaken":"Reported 91 times (LLR=172)"},{"llr":166.299,"date":"","count":39,"signal":"Blood phosphorus increased","source":"DrugCentral FAERS","actionTaken":"Reported 39 times (LLR=166)"},{"llr":141.561,"date":"","count":40,"signal":"Appendicitis","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=142)"},{"llr":141.057,"date":"","count":53,"signal":"Pneumonia aspiration","source":"DrugCentral FAERS","actionTaken":"Reported 53 times (LLR=141)"},{"llr":126.165,"date":"","count":40,"signal":"Ventricular fibrillation","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=126)"},{"llr":121.091,"date":"","count":53,"signal":"Coma","source":"DrugCentral FAERS","actionTaken":"Reported 53 times (LLR=121)"},{"llr":119.296,"date":"","count":32,"signal":"Blood uric acid increased","source":"DrugCentral FAERS","actionTaken":"Reported 32 times (LLR=119)"},{"llr":118.342,"date":"","count":55,"signal":"Gastrooesophageal reflux disease","source":"DrugCentral FAERS","actionTaken":"Reported 55 times (LLR=118)"},{"llr":116.556,"date":"","count":40,"signal":"Cardiogenic shock","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=117)"}],"commonSideEffects":[{"effect":"Appendicolith","drugRate":"LLR 181","severity":"common"},{"effect":"Somnolence","drugRate":"LLR 172","severity":"common"},{"effect":"Blood phosphorus increased","drugRate":"LLR 166","severity":"common"},{"effect":"Appendicitis","drugRate":"LLR 142","severity":"common"},{"effect":"Pneumonia aspiration","drugRate":"LLR 141","severity":"common"},{"effect":"Ventricular fibrillation","drugRate":"LLR 126","severity":"common"},{"effect":"Coma","drugRate":"LLR 121","severity":"common"},{"effect":"Blood uric acid increased","drugRate":"LLR 119","severity":"common"},{"effect":"Gastrooesophageal reflux disease","drugRate":"LLR 118","severity":"common"},{"effect":"Cardiogenic shock","drugRate":"LLR 117","severity":"common"}],"contraindications":["Anorexia nervosa","Kidney disease"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"aminobenzoate potassium","offLabel":[],"synonyms":["4-aminobenzoic acid","aminobenzoate potassium","p-aminobenzoic acid","4-aminobenzenecarboxylic acid","4-carboxy phenyl aniline","aminobenzoic acid","4-Aminobenzoate"],"timeline":[],"brandName":"Aminobenzoate Potassium","ecosystem":[{"indication":"Dermatomyositis","otherDrugs":[{"name":"azathioprine","slug":"azathioprine","company":"Prometheus Labs"},{"name":"benzoic acid","slug":"benzoic-acid","company":""}],"globalPrevalence":602496},{"indication":"Induratio penis plastica","otherDrugs":[{"name":"benzoic acid","slug":"benzoic-acid","company":""},{"name":"collagenase","slug":"collagenase","company":"Advance Biofactures"}],"globalPrevalence":null},{"indication":"Morphea","otherDrugs":[{"name":"benzoic acid","slug":"benzoic-acid","company":""}],"globalPrevalence":null},{"indication":"Pemphigus","otherDrugs":[{"name":"benzoic acid","slug":"benzoic-acid","company":""},{"name":"betamethasone","slug":"betamethasone","company":""},{"name":"betamethasone acetate","slug":"betamethasone-acetate","company":""},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""}],"globalPrevalence":1440000},{"indication":"Systemic sclerosis","otherDrugs":[{"name":"benzoic acid","slug":"benzoic-acid","company":""},{"name":"bosentan","slug":"bosentan","company":"Actelion Pharms Ltd"},{"name":"rituximab","slug":"rituximab","company":"Genentech"}],"globalPrevalence":136000000}],"mechanism":{"target":"Carbonic anhydrase 2","targets":[{"gene":"CA2","source":"DrugCentral","target":"Carbonic anhydrase 2","protein":"Carbonic anhydrase 2"},{"gene":"CA1","source":"DrugCentral","target":"Carbonic anhydrase 1","protein":"Carbonic anhydrase 1"}],"modality":"Small Molecule","drugClass":"Vitamin B Complex Member","explanation":"Think of carbonic anhydrase 2 like a thermostat in your body. It helps keep the pH levels in your cells just right. When this enzyme gets out of balance, it can lead to various skin problems. Aminobenzoate Potassium helps restore balance by blocking the enzyme's activity, reducing inflammation and promoting healing.","oneSentence":"Aminobenzoate Potassium works by inhibiting the enzyme carbonic anhydrase 2, which plays a crucial role in maintaining the pH balance in cells.","technicalDetail":"Aminobenzoate Potassium acts as a competitive inhibitor of carbonic anhydrase 2, preventing the enzyme from catalyzing the reversible hydration of carbon dioxide to bicarbonate and protons, thereby reducing the production of protons and subsequent acidification of the cellular environment."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2049","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=aminobenzoic%20acid","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=aminobenzoic acid","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:40:56.695799","biosimilars":[],"competitors":[{"drugName":"octinoxate","drugSlug":"octinoxate","fdaApproval":"1992-12-07","relationship":"same-class"}],"genericName":"aminobenzoic acid","indications":{"approved":[{"name":"Dermatomyositis","source":"DrugCentral","snomedId":396230008,"regulator":"FDA","usPrevalence":null,"globalPrevalence":602496,"prevalenceMethod":"curated","prevalenceSource":"Orphanet (36581896[PMID]_ORPHANET)"},{"name":"Induratio penis 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