{"id":"amine-fluoride-stannous-fluoride","safety":{"commonSideEffects":[{"rate":null,"effect":"Dental fluorosis (with excessive ingestion)"},{"rate":null,"effect":"Mild tooth sensitivity"},{"rate":null,"effect":"Staining or discoloration"}]},"_chembl":{"chemblId":"CHEMBL1909079","moleculeType":"Small molecule","molecularWeight":"156.71"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluoride ions from both compounds are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization. Stannous ions provide additional antimicrobial activity against cariogenic bacteria, reducing acid production. Together, these agents provide dual protection against tooth decay through both remineralization and bacterial inhibition.","oneSentence":"Amine fluoride and stannous fluoride work together to strengthen tooth enamel and inhibit bacterial acid production to prevent dental caries.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:21:24.364Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of dental caries (cavities)"},{"name":"Tooth enamel strengthening"}]},"trialDetails":[{"nctId":"NCT02740803","phase":"NA","title":"Total Salivary Fluoride Concentration of Healthy Adult Subjects Following Toothbrushing With Different Formulations of Fluoridated Toothpastes With and Without Post-brushing Water Rinsing.","status":"COMPLETED","sponsor":"University of Leeds","startDate":"2016-04","conditions":"Caries","enrollment":120},{"nctId":"NCT01747226","phase":"NA","title":"Effect of Mouth Rinses in Oral Malodor","status":"UNKNOWN","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2013-03","conditions":"Halitosis","enrollment":96},{"nctId":"NCT01317446","phase":"PHASE4","title":"Effect of Mouthrinsing on Inflammation of the Gums.","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2010-11","conditions":"Gingivitis","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":69,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["meridol"],"phase":"marketed","status":"active","brandName":"amine fluoride/stannous fluoride","genericName":"amine fluoride/stannous fluoride","companyName":"Technische Universität Dresden","companyId":"technische-universit-t-dresden","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Amine fluoride/stannous fluoride is used in mouth rinses to treat conditions such as halitosis, gingivitis, and caries, as indicated by studies on ClinicalTrials.gov. The mechanism of action is not specified in the provided facts, but it is listed as an intervention in various studies on ClinicalTrials.gov and has a ChEMBL ID, suggesting it is a known compound with a defined chemical structure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}