{"id":"aminaphthone","rwe":[{"pmid":"39861707","year":"2025","title":"Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"38015554","year":"2023","title":"Systematic literature review and expert meeting report on health-related quality of life in chronic venous disease.","finding":"","journal":"International angiology : a journal of the International Union of Angiology","studyType":"Clinical Study"},{"pmid":"23761871","year":"2014","title":"Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial.","finding":"","journal":"Phlebology","studyType":"Clinical Study"},{"pmid":"306333","year":"1978","title":"[Therapeutic activity of aminaphthone in purpuric disorders].","finding":"","journal":"La Clinica terapeutica","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Coagulants","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Hemostatics","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"aminaftone","offLabel":[],"synonyms":["aminaftone","aminaphthone"],"timeline":[],"brandName":"Aminaftone","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like a complex orchestra, with many different instruments working together to create a symphony. Aminaftone is like a new instrument that's being introduced to the orchestra, but we don't yet know how it will fit in or what it will sound like. As researchers learn more about how aminaftone interacts with the cells, they can begin to understand how it might be used to treat certain conditions.","oneSentence":"Aminaftone works by interacting with specific biological pathways, but the exact mechanism is unknown.","technicalDetail":"Aminaftone's mechanism of action is currently unknown, but it is likely to involve binding to specific receptors or enzymes, triggering a cascade of downstream effects that ultimately lead to its therapeutic or adverse effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/159","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=aminaphthone","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=aminaphthone","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:42:58.738277","biosimilars":[],"competitors":[],"genericName":"aminaphthone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07026513","phase":"","title":"ORal Aminaphtone and Combined LidocainE","status":"RECRUITING","sponsor":"Treviso Regional Hospital","startDate":"2025-05-08","conditions":["Hemorrhoid"],"enrollment":50,"completionDate":"2025-07-31"},{"nctId":"NCT02149212","phase":"PHASE4","title":"Iliac Vein Stenting in Advanced Chronic Venous Insufficiency","status":"COMPLETED","sponsor":"Instituto Dante Pazzanese de Cardiologia","startDate":"2013-02","conditions":["Iliac Vein Obstruction","May-Thurner Syndrome","Cockett Syndrome"],"enrollment":50,"completionDate":"2014-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"009051","UNII":"03JLX11PE9","CHEBI":"CHEBI:135317","RXNORM":"46276","UMLSCUI":"C0051601","DRUGBANK_ID":"DB13039","PUBCHEM_CID":"84621","MESH_SUPPLEMENTAL_RECORD_UI":"C016217"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Jan 3","pmid":"39861707","title":"Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances.","journal":"Pharmaceutics"},{"date":"2023 Dec","pmid":"38015554","title":"Systematic literature review and expert meeting report on health-related quality of life in chronic venous disease.","journal":"International angiology : a journal of the International Union of Angiology"},{"date":"2014 Aug","pmid":"23761871","title":"Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial.","journal":"Phlebology"},{"date":"1978 Mar 15","pmid":"306333","title":"[Therapeutic activity of aminaphthone in purpuric disorders].","journal":"La Clinica terapeutica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Aminaphtone is being studied as a phlebotonic intervention for conditions such as hemorrhoids, iliac vein obstruction, May-Thurner Syndrome, and Cockett Syndrome. It is also being used in combination with lidocaine cream in a first-line therapy for hemorrhoidal disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}