{"id":"amidefrine","rwe":[],"tags":[{"label":"amidefrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic alpha-Agonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"amidephrine","offLabel":[],"synonyms":["amidefrine mesilate","amidephrine","amidefrine","(+/-)-Amidephrine","amidephrine mesylate","amidefrine mesylate","amidephrine mesilate"],"timeline":[],"brandName":"Amidephrine","ecosystem":[],"mechanism":{"target":"Adrenergic receptor alpha-1, Adrenergic receptor alpha-2","modality":"Small Molecule","drugClass":"amidefrine","explanation":"Imagine your body's 'fight or flight' response, where your heart beats faster and your blood pressure rises to help you react quickly to a threat. Amidephrine is thought to trigger this response by stimulating the nerves that control these functions. This can be useful in certain medical situations, but more research is needed to understand its effects and potential uses.","oneSentence":"Amidephrine works by stimulating the sympathetic nervous system, which can increase heart rate and blood pressure.","technicalDetail":"Amidephrine is believed to act as a sympathomimetic agent, mimicking the effects of the neurotransmitters norepinephrine and epinephrine to increase sympathetic tone and stimulate the body's 'fight or flight' response."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/155","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=amidefrine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:40:11.835252","biosimilars":[],"competitors":[{"drugName":"apomorphine","drugSlug":"apomorphine","fdaApproval":"2004-04-20","patentExpiry":"Jun 11, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"brimonidine","drugSlug":"brimonidine","fdaApproval":"1996-09-06","patentExpiry":"Mar 25, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"bromocriptine","drugSlug":"bromocriptine","fdaApproval":"1978-06-28","patentExpiry":"Jun 7, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"buspirone","drugSlug":"buspirone","fdaApproval":"1986-09-29","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"cisapride","drugSlug":"cisapride","fdaApproval":"1993-07-29","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"clomipramine","drugSlug":"clomipramine","fdaApproval":"1989-12-29","genericCount":19,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clonidine","drugSlug":"clonidine","fdaApproval":"1974-09-03","patentExpiry":"Sep 8, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"clozapine","drugSlug":"clozapine","fdaApproval":"1989-09-26","patentExpiry":"May 1, 2028","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"corbadrine","drugSlug":"corbadrine","fdaApproval":"1960-01-06","relationship":"same-target"},{"drugName":"dexmedetomidine","drugSlug":"dexmedetomidine","fdaApproval":"1999-12-17","patentExpiry":"Jun 26, 2039","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"amidefrine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"apomorphine","brandName":"apomorphine","genericName":"apomorphine","approvalYear":"2004","relationship":"same-target"},{"drugId":"brimonidine","brandName":"brimonidine","genericName":"brimonidine","approvalYear":"1996","relationship":"same-target"},{"drugId":"bromocriptine","brandName":"bromocriptine","genericName":"bromocriptine","approvalYear":"1978","relationship":"same-target"},{"drugId":"buspirone","brandName":"buspirone","genericName":"buspirone","approvalYear":"1986","relationship":"same-target"},{"drugId":"cisapride","brandName":"cisapride","genericName":"cisapride","approvalYear":"1993","relationship":"same-target"},{"drugId":"clomipramine","brandName":"clomipramine","genericName":"clomipramine","approvalYear":"1989","relationship":"same-target"},{"drugId":"clonidine","brandName":"clonidine","genericName":"clonidine","approvalYear":"1974","relationship":"same-target"},{"drugId":"clozapine","brandName":"clozapine","genericName":"clozapine","approvalYear":"1989","relationship":"same-target"},{"drugId":"corbadrine","brandName":"corbadrine","genericName":"corbadrine","approvalYear":"1960","relationship":"same-target"},{"drugId":"dexmedetomidine","brandName":"dexmedetomidine","genericName":"dexmedetomidine","approvalYear":"1999","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"7E2P22546V","CHEBI":"CHEBI:134994","INN_ID":"1751","UMLSCUI":"C0051584","ChEMBL_ID":"CHEMBL146408","KEGG_DRUG":"D02901","DRUGBANK_ID":"DB16623","PUBCHEM_CID":"15010","IUPHAR_LIGAND_ID":"514","SECONDARY_CAS_RN":"1421-68-7","MESH_SUPPLEMENTAL_RECORD_UI":"C016980"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Amidephrine is a small molecule. It is also known by several synonyms, including 5190, Amidephrine Mesilate, Amidephine, and Amidephine Mesilate.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}