{"id":"amfetaminil","rwe":[],"tags":[{"label":"amfetaminil","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Narcolepsy","category":"indication"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"aponeuron","offLabel":[],"synonyms":["amphetaminil","amfetaminil","aponeuron","dl-Amphetaminil"],"timeline":[],"brandName":"Aponeuron","ecosystem":[{"indication":"Narcolepsy","otherDrugs":[{"name":"amfetamine","slug":"amfetamine","company":"Ucb Inc"},{"name":"armodafinil","slug":"armodafinil","company":"Cephalon"},{"name":"dexamfetamine","slug":"dexamfetamine","company":"Ucb Inc"},{"name":"methylphenidate","slug":"methylphenidate","company":"Novartis"}],"globalPrevalence":2400000}],"mechanism":{"modality":"Small Molecule","drugClass":"amfetaminil","explanation":"Imagine your brain is a city, and the neurotransmitters are the messengers that help different parts of the city communicate. Aponeuron helps increase the number of these messengers, making it easier for the city to stay awake and alert. This is similar to how a stimulant like caffeine works, but Aponeuron is a more targeted and specific medication.","oneSentence":"Aponeuron works by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine, to enhance alertness and wakefulness.","technicalDetail":"Aponeuron is a non-catecholamine, non-amphetamine stimulant that acts as a norepinephrine-dopamine reuptake inhibitor (NDRI), increasing the levels of these neurotransmitters in the synaptic cleft and enhancing their activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/196","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AMFETAMINIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:40:22.756108","biosimilars":[],"competitors":[],"genericName":"amfetaminil","indications":{"approved":[{"name":"Narcolepsy","source":"DrugCentral","snomedId":60380001,"regulator":"FDA","usPrevalence":null,"globalPrevalence":2400000,"prevalenceMethod":"curated","prevalenceSource":"Orphanet (24849861[PMID]_[EXPERT])"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007125","UNII":"0XU0V77JVE","CHEBI":"CHEBI:135022","INN_ID":"4471","RXNORM":"17813","UMLSCUI":"C2698084","ChEMBL_ID":"CHEMBL2104064","KEGG_DRUG":"D07446","PUBCHEM_CID":"28615","SNOMEDCT_US":"96239007","MESH_SUPPLEMENTAL_RECORD_UI":"C100229"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Aponeuron, also known as amfetaminil, is a small molecule drug in the amfetaminil class. It is used to treat narcolepsy, a neurological disorder characterized by excessive daytime sleepiness. The commercial status of Aponeuron is currently unknown, and it is not clear if it is patented or available as a generic medication. Aponeuron's safety considerations are not well-documented, but it is likely to have similar side effects to other stimulant medications. Further research is needed to fully understand the pharmacology and safety of Aponeuron.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}