{"id":"amezinium-metilsulfate","rwe":[],"tags":[{"label":"Monoamine Oxidase Inhibitors","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C01CA25","category":"atc"},{"label":"Active","category":"status"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Monoamine Oxidase Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":40.608,"date":"","count":7,"signal":"Shunt occlusion","source":"DrugCentral FAERS","actionTaken":"Reported 7 times (LLR=41)"}],"drugInteractions":[{"url":"/drug/alpha/beta-agonists","drug":"Alpha/Beta Agonists","action":"Use caution","effect":"MAO Inhibitors may enhance the hypertensive effect of Alpha/Beta-Agonists","source":"DrugCentral","drugSlug":"alpha/beta-agonists"},{"url":"/drug/amphetamines","drug":"Amphetamines","action":"Use caution","effect":"MAO Inhibitors may enhance the hypertensive effect of amphetamines","source":"DrugCentral","drugSlug":"amphetamines"},{"url":"/drug/indirectly-acting-sympathomimetic-amines","drug":"Indirectly Acting Sympathomimetic Amines","action":"Contraindicated","effect":"potentially fatal hypertensive crisis","source":"DrugCentral","drugSlug":"indirectly-acting-sympathomimetic-amines"},{"url":"/drug/selective-serotonin-reuptake-inhibitors","drug":"Selective Serotonin Reuptake Inhibitors","action":"Contraindicated","effect":"serotonin syndrome","source":"DrugCentral","drugSlug":"selective-serotonin-reuptake-inhibitors"},{"url":"/drug/serotonin/norepinephrine-reuptake-inhibitors","drug":"Serotonin/Norepinephrine Reuptake Inhibitors","action":"Contraindicated","effect":"serotonin syndrome","source":"DrugCentral","drugSlug":"serotonin/norepinephrine-reuptake-inhibitors"},{"url":"/drug/tricyclic-antidepressants","drug":"Tricyclic Antidepressants","action":"Contraindicated","effect":"very toxic and sometimes fatal reactions the serotonin syndrome or similar","source":"DrugCentral","drugSlug":"tricyclic-antidepressants"},{"url":"/drug/buspirone","drug":"buspirone","action":"Use caution","effect":"May increase blood pressure","source":"DrugCentral","drugSlug":"buspirone"},{"url":"/drug/dextromethorphan","drug":"dextromethorphan","action":"Contraindicated","effect":"fatal/non-fatal reactions","source":"DrugCentral","drugSlug":"dextromethorphan"},{"url":"/drug/levodopa","drug":"levodopa","action":"Contraindicated","effect":"life-threatening hypertensive reaction","source":"DrugCentral","drugSlug":"levodopa"},{"url":"/drug/methyldopa","drug":"methyldopa","action":"Use caution","effect":"hypertension may occur","source":"DrugCentral","drugSlug":"methyldopa"},{"url":"/drug/mirtazapine","drug":"mirtazapine","action":"Contraindicated","effect":"Label warning","source":"DrugCentral","drugSlug":"mirtazapine"},{"url":"/drug/pethidine","drug":"pethidine","action":"Use caution","effect":"potentially life-threatening reaction","source":"DrugCentral","drugSlug":"pethidine"},{"url":"/drug/phenylephrine","drug":"phenylephrine","action":"Contraindicated","effect":"potentially fatal hypertensive crisis","source":"DrugCentral","drugSlug":"phenylephrine"},{"url":"/drug/tramadol","drug":"tramadol","action":"Use caution","effect":"serotonin syndrome","source":"DrugCentral","drugSlug":"tramadol"},{"url":"/drug/tryptophan","drug":"tryptophan","action":"Contraindicated","effect":"severe behavioural and neurological signs of toxicity","source":"DrugCentral","drugSlug":"tryptophan"}],"commonSideEffects":[{"effect":"Shunt occlusion","drugRate":"LLR 41","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"regulton","offLabel":[],"synonyms":["amezinium methyl sulfate","amezinium","amezinium metilsulfate","regulton"],"timeline":[],"brandName":"Regulton","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Monoamine Oxidase Inhibitors","explanation":"Think of it like a traffic cop at a busy intersection. Monoamine oxidase is like the cop that stops certain 'cars' (neurotransmitters like serotonin and dopamine) from getting through. Regulton is like a sign that says 'go ahead, let the cars through'. This allows more of these neurotransmitters to be available in the brain, which can help improve mood and other symptoms.","oneSentence":"Regulton works by inhibiting the enzyme monoamine oxidase, which breaks down certain neurotransmitters in the brain.","technicalDetail":"Regulton (Amesiniium Metilsulfate) is a reversible, non-selective inhibitor of monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), with a half-life of 14.1 hours and bioavailability of 58%."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/153","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AMEZINIUM METILSULFATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:40:18.820640","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:02:39.734414+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"isoprenaline","drugSlug":"isoprenaline","fdaApproval":"1956-03-09","relationship":"same-class"},{"drugName":"norepinephrine","drugSlug":"norepinephrine","fdaApproval":"1950-07-13","patentExpiry":"Mar 8, 2041","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dopamine","drugSlug":"dopamine","fdaApproval":"1974-02-25","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"phenylephrine","drugSlug":"phenylephrine","fdaApproval":"1952-01-21","patentExpiry":"Sep 26, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"dobutamine","drugSlug":"dobutamine","fdaApproval":"1978-07-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metaraminol","drugSlug":"metaraminol","fdaApproval":"1954-09-29","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methoxamine","drugSlug":"methoxamine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"mephentermine","drugSlug":"mephentermine","fdaApproval":"1951-12-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"midodrine","drugSlug":"midodrine","fdaApproval":"1996-09-06","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fenoldopam","drugSlug":"fenoldopam","fdaApproval":"1997-09-23","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"arbutamine","drugSlug":"arbutamine","fdaApproval":"1997-09-12","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"epinephrine","drugSlug":"epinephrine","fdaApproval":"1948-11-19","patentExpiry":"Oct 20, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ephedrine","drugSlug":"ephedrine","fdaApproval":"","patentExpiry":"May 16, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"droxidopa","drugSlug":"droxidopa","fdaApproval":"2014-02-18","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"amezinium metilsulfate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"isoprenaline","brandName":"isoprenaline","genericName":"isoprenaline","approvalYear":"1956","relationship":"same-class"},{"drugId":"norepinephrine","brandName":"norepinephrine","genericName":"norepinephrine","approvalYear":"1950","relationship":"same-class"},{"drugId":"dopamine","brandName":"dopamine","genericName":"dopamine","approvalYear":"1974","relationship":"same-class"},{"drugId":"phenylephrine","brandName":"phenylephrine","genericName":"phenylephrine","approvalYear":"1952","relationship":"same-class"},{"drugId":"dobutamine","brandName":"dobutamine","genericName":"dobutamine","approvalYear":"1978","relationship":"same-class"},{"drugId":"metaraminol","brandName":"metaraminol","genericName":"metaraminol","approvalYear":"1954","relationship":"same-class"},{"drugId":"methoxamine","brandName":"methoxamine","genericName":"methoxamine","approvalYear":"","relationship":"same-class"},{"drugId":"mephentermine","brandName":"mephentermine","genericName":"mephentermine","approvalYear":"1951","relationship":"same-class"},{"drugId":"midodrine","brandName":"midodrine","genericName":"midodrine","approvalYear":"1996","relationship":"same-class"},{"drugId":"fenoldopam","brandName":"fenoldopam","genericName":"fenoldopam","approvalYear":"1997","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004308","UNII":"03NR868ICX","CHEBI":"CHEBI:31201","INN_ID":"4066","RXNORM":"17665","UMLSCUI":"C0771147","ChEMBL_ID":"CHEMBL2106667","KEGG_DRUG":"D01304","DRUGBANK_ID":"DB13330","PUBCHEM_CID":"71926","SECONDARY_CAS_RN":"41658-78-0","MESH_SUPPLEMENTAL_RECORD_UI":"C027784"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"14.1 hours","clearance":"5.1 mL/min/kg","bioavailability":"58%","volumeOfDistribution":"4.0 L/kg"},"publicationCount":0,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"C01CA25","allCodes":["C01CA25"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Regulton is a small molecule medication. It is also known by various synonyms, including Amezinium methyl sulfate.","enrichmentLevel":5,"visitCount":1,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:02:39.734414+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}