{"id":"ambutonium","rwe":[{"pmid":"6265591","year":"1981","title":"Inactivation of potassium current in squid axon by a variety of quaternary ammonium ions.","finding":"","journal":"The Journal of general physiology","studyType":"Clinical Study"},{"pmid":"6747","year":"1976","title":"Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives.","finding":"","journal":"The Journal of pharmacy and pharmacology","studyType":"Clinical Study"},{"pmid":"4401084","year":"1972","title":"Central and peripheral actions of the acetylcholine antagonist, ambutonium bromide.","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"14089172","year":"1963","title":"[THERAPEUTIC EVALUATION OF AMBUTONIUM BROMIDE IN PEPTIC ULCER].","finding":"","journal":"Polski tygodnik lekarski (Warsaw, Poland : 1960)","studyType":"Clinical Study"},{"pmid":"14487446","year":"1961","title":"[A new anticholinergic agent: Ambutonium, in the treatment of ulcerous disease].","finding":"","journal":"La Semaine des hopitaux: therapeutique","studyType":"Clinical Study"}],"tags":[{"label":"ambutonium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A03CA07","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["ambutonium","ambutonium bromide"],"offLabel":[],"synonyms":["ambutonium","ambutonium bromide"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"ambutonium","explanation":"Unfortunately, the exact mechanism of action for ambutonium is not well understood, but it is thought to work by binding to a specific receptor or enzyme to produce a desired response. This interaction can lead to changes in the body's physiological processes, resulting in therapeutic benefits. However, without more information, it is difficult to provide a detailed explanation of how ambutonium works.","oneSentence":"Ambutonium is a small molecule that works by interacting with a specific target to produce a therapeutic effect.","technicalDetail":"As a small molecule in the ambutonium class, ambutonium is likely to work through a specific molecular interaction, such as competitive inhibition or allosteric modulation, to produce its therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/149","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ambutonium","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:40:14.951804","biosimilars":[],"competitors":[{"drugName":"isopropamide","drugSlug":"isopropamide","fdaApproval":"1957-10-09","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"clidinium","drugSlug":"clidinium","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"oxyphencyclimine","drugSlug":"oxyphencyclimine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"glycopyrronium bromide","drugSlug":"glycopyrronium-bromide","fdaApproval":"1961-08-11","relationship":"same-class"},{"drugName":"diphemanil","drugSlug":"diphemanil","fdaApproval":"1976-05-17","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"propantheline","drugSlug":"propantheline","fdaApproval":"1953-04-02","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"ambutonium","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"isopropamide","brandName":"isopropamide","genericName":"isopropamide","approvalYear":"1957","relationship":"same-class"},{"drugId":"clidinium","brandName":"clidinium","genericName":"clidinium","approvalYear":"","relationship":"same-class"},{"drugId":"oxyphencyclimine","brandName":"oxyphencyclimine","genericName":"oxyphencyclimine","approvalYear":"","relationship":"same-class"},{"drugId":"glycopyrronium-bromide","brandName":"glycopyrronium bromide","genericName":"glycopyrronium bromide","approvalYear":"1961","relationship":"same-class"},{"drugId":"diphemanil","brandName":"diphemanil","genericName":"diphemanil","approvalYear":"1976","relationship":"same-class"},{"drugId":"propantheline","brandName":"propantheline","genericName":"propantheline","approvalYear":"1953","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003925","UNII":"4O677EQ77U","CHEBI":"CHEBI:135331","UMLSCUI":"C0301368","ChEMBL_ID":"CHEMBL2110771","PUBCHEM_CID":"8277","SNOMEDCT_US":"28702005","SECONDARY_CAS_RN":"115-51-5"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"A03CA07","allCodes":["A03CA07"]},"biosimilarFilings":[],"recentPublications":[{"date":"1981 Mar","pmid":"6265591","title":"Inactivation of potassium current in squid axon by a variety of quaternary ammonium ions.","journal":"The Journal of general physiology"},{"date":"1976 May","pmid":"6747","title":"Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives.","journal":"The Journal of pharmacy and pharmacology"},{"date":"1972 Apr","pmid":"4401084","title":"Central and peripheral actions of the acetylcholine antagonist, ambutonium bromide.","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1963 Sep 9","pmid":"14089172","title":"[THERAPEUTIC EVALUATION OF AMBUTONIUM BROMIDE IN PEPTIC ULCER].","journal":"Polski tygodnik lekarski (Warsaw, Poland : 1960)"},{"date":"1961 Dec","pmid":"14487446","title":"[A new anticholinergic agent: Ambutonium, in the treatment of ulcerous disease].","journal":"La Semaine des hopitaux: therapeutique"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"ambutonium","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Ambutonium is a small molecule drug in the ambutonium class, but specific details about its development, approval status, and commercial availability are not available. As a result, there is limited information on its target, approved indications, half-life, bioavailability, and generic manufacturers. The mechanism of action and key safety considerations for ambutonium are also unclear. Further research is needed to understand the pharmacological properties and clinical applications of this drug. Without more information, it is challenging to provide a comprehensive summary of ambutonium.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}