{"id":"aluminium-clofibrate","rwe":[{"pmid":"2397479","year":"1990","title":"Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators; di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate.","finding":"","journal":"Cancer letters","studyType":"Clinical Study"},{"pmid":"3332236","year":"1987","title":"The antilipemic effectiveness of aluminium clofibrate on hyperlipidemic patients with or without diabetes mellitus.","finding":"","journal":"Zhonghua yi xue za zhi = Chinese medical journal; Free China ed","studyType":"Clinical Study"},{"pmid":"4908720","year":"1970","title":"[Study of the action of basic aluminium clofibrate on blood lipids and hemostasis].","finding":"","journal":"Therapeutique (La Semaine des hopitaux)","studyType":"Clinical Study"}],"tags":[{"label":"aluminium clofibrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C10AB03","category":"atc"},{"label":"Active","category":"status"},{"label":"Anticholesteremic Agents","category":"pharmacology"},{"label":"Antimetabolites","category":"pharmacology"},{"label":"Hypolipidemic Agents","category":"pharmacology"},{"label":"Lipid Regulating Agents","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["aluminium clofibrate"],"offLabel":[],"synonyms":["aluminium clofibrate"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"aluminium clofibrate","explanation":"Think of it like a traffic cop for your body's fat breakdown. Aluminium clofibrate helps slow down the liver's 'fat recycling' process, which can help lower the amount of fat in your blood. This can be beneficial for people with high triglyceride levels, which can increase the risk of heart disease.","oneSentence":"Aluminium clofibrate works by inhibiting the breakdown of lipids in the liver, thereby reducing triglyceride levels in the blood.","technicalDetail":"Aluminium clofibrate is a fibric acid derivative that inhibits the activity of lipoprotein lipase, a key enzyme involved in the breakdown of triglycerides in the liver."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Aluminium_clofibrate","title":"Aluminium clofibrate","extract":"Aluminium clofibrate is a fibrate."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4437","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=aluminium clofibrate","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Aluminium_clofibrate","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:38:59.611808","biosimilars":[],"competitors":[{"drugName":"clofibrate","drugSlug":"clofibrate","fdaApproval":"1967-02-08","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"gemfibrozil","drugSlug":"gemfibrozil","fdaApproval":"1981-12-21","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fenofibrate","drugSlug":"fenofibrate","fdaApproval":"1993-12-31","patentExpiry":"May 31, 2033","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"choline fenofibrate","drugSlug":"choline-fenofibrate","fdaApproval":"2008-12-15","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"aluminium clofibrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clofibrate","brandName":"clofibrate","genericName":"clofibrate","approvalYear":"1967","relationship":"same-class"},{"drugId":"gemfibrozil","brandName":"gemfibrozil","genericName":"gemfibrozil","approvalYear":"1981","relationship":"same-class"},{"drugId":"fenofibrate","brandName":"fenofibrate","genericName":"fenofibrate","approvalYear":"1993","relationship":"same-class"},{"drugId":"choline-fenofibrate","brandName":"choline fenofibrate","genericName":"choline fenofibrate","approvalYear":"2008","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005585","CHEBI":"CHEBI:34648","INN_ID":"2439","UMLSCUI":"C0051149","ChEMBL_ID":"CHEMBL3833336","DRUGBANK_ID":"DB13780","PUBCHEM_CID":"16683028","MESH_DESCRIPTOR_UI":"D002995"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Metabolic"],"atcClassification":{"source":"DrugCentral","atcCode":"C10AB03","allCodes":["C10AB03"]},"biosimilarFilings":[],"recentPublications":[{"date":"1990 Aug","pmid":"2397479","title":"Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators; di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate.","journal":"Cancer letters"},{"date":"1987 Nov","pmid":"3332236","title":"The antilipemic effectiveness of aluminium clofibrate on hyperlipidemic patients with or without diabetes mellitus.","journal":"Zhonghua yi xue za zhi = Chinese medical journal; Free China ed"},{"date":"1970 Jan","pmid":"4908720","title":"[Study of the action of basic aluminium clofibrate on blood lipids and hemostasis].","journal":"Therapeutique (La Semaine des hopitaux)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"aluminium clofibrate","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Aluminium clofibrate is a small molecule drug in the aluminium clofibrate class, but its original developer and current owner are unknown. Its target and approved indications are also not specified. The drug's commercial status, including whether it is patented or generic, and its off-patent status are unknown. Aluminium clofibrate's half-life, bioavailability, and FDA approval status are also not available. Further information on this drug is required for a comprehensive understanding of its use and safety.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}