{"id":"altropane","rwe":[{"pmid":"40926089","year":"2026","title":"Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation.","finding":"","journal":"Molecular psychiatry","studyType":"Clinical Study"},{"pmid":"31243072","year":"2019","title":"Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease.","finding":"","journal":"Neurology","studyType":"Clinical Study"},{"pmid":"31042280","year":"2019","title":"Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence.","finding":"","journal":"JAMA psychiatry","studyType":"Clinical Study"},{"pmid":"26655867","year":"2016","title":"PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies.","finding":"","journal":"Neuro-degenerative diseases","studyType":"Clinical Study"},{"pmid":"26137443","year":"2015","title":"Putamen-midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases.","finding":"","journal":"NeuroImage. Clinical","studyType":"Clinical Study"}],"tags":[{"label":"altropane","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["altropane"],"offLabel":[],"synonyms":["altropane"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"altropane","explanation":"Think of ALTROPANE like a key that fits into a lock. The lock is a specific protein in the body, and when the key (ALTROPANE) binds to it, it can either turn off or turn on a particular process. This process is what we're trying to understand and control with ALTROPANE.","oneSentence":"ALTROPANE works by binding to and inhibiting a specific target, although the exact target is unknown.","technicalDetail":"ALTROPANE is a small molecule that interacts with a specific protein target, although the exact nature of this interaction is not specified. Further research is needed to elucidate the pharmacokinetic and pharmacodynamic properties of ALTROPANE."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3292","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ALTROPANE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALTROPANE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:38:50.977946","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:40:51.874927+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"altropane","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05636852","phase":"PHASE2","title":"Altropane Dose for Imaging Patients With Suspected Parkinson's Disease","status":"TERMINATED","sponsor":"GE Healthcare","startDate":"2023-04-24","conditions":["Parkinson Disease","Movement Disorders"],"enrollment":15,"completionDate":"2024-06-08"},{"nctId":"NCT01701141","phase":"","title":"Depression and Dopamine Transporter Function Study Using C-11 Altropane","status":"COMPLETED","sponsor":"Mclean Hospital","startDate":"2012-01","conditions":["Major Depressive Disorder","Anhedonia"],"enrollment":150,"completionDate":"2014-07"},{"nctId":"NCT00397228","phase":"PHASE2","title":"ALTROPANE® SPECT Imaging in Patients With Parkinson Disease","status":"COMPLETED","sponsor":"Molecular NeuroImaging","startDate":"2006-11","conditions":["Parkinson Disease"],"enrollment":27,"completionDate":"2011-12"},{"nctId":"NCT00593138","phase":"PHASE1,PHASE2","title":"Study of Dopamine Transporter Receptor Occupancy With Long-acting Dex-methylphenidate","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2006-12","conditions":["Drug Binding to DAT Receptors"],"enrollment":23,"completionDate":"2009-12"},{"nctId":"NCT00302367","phase":"PHASE4","title":"An Open Label Phase I/II Study of Dopamine Transporter Receptor Occupancy With OROS and Immediate Release Methylphenidate as Measured With C-11 Altropane in Human Subjects","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2004-01","conditions":["Healthy Volunteers"],"enrollment":20,"completionDate":"2004-04"},{"nctId":"NCT00302380","phase":"","title":"An Open Label Phase I/II Study of the Safety and Dopamine Transporter Binding Properties of C-11 Altropane in Normal Human Subjects and in Subjects With ADHD","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2000-10","conditions":["Attention Deficit Hyperactivity Disorder"],"enrollment":300,"completionDate":"2006-03"},{"nctId":"NCT00724906","phase":"PHASE3","title":"Two Separate But Identical Studies Evaluating the Safety and Efficacy of ALTROPANE® in the Use of SPECT Imaging for Upper Extremity Tremor","status":"UNKNOWN","sponsor":"Alseres Pharmaceuticals, Inc","startDate":"2010-07","conditions":["Parkinsonian Syndromes"],"enrollment":240,"completionDate":"2011-07"},{"nctId":"NCT00596908","phase":"","title":"123I-ALTROPANE® Reference Image Acquisition in Subjects With Diagnostically Uncertain Tremor","status":"COMPLETED","sponsor":"Alseres Pharmaceuticals, Inc","startDate":"2007-12","conditions":["Upper Extremity Tremor"],"enrollment":54,"completionDate":"2009-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"1Q4092099O","UMLSCUI":"C0663483","ChEMBL_ID":"CHEMBL4301492","DRUGBANK_ID":"DB04947","PUBCHEM_CID":"6440180","MESH_SUPPLEMENTAL_RECORD_UI":"C102282"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":28,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan","pmid":"40926089","title":"Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation.","journal":"Molecular psychiatry"},{"date":"2019 Jul 30","pmid":"31243072","title":"Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease.","journal":"Neurology"},{"date":"2019 Aug 1","pmid":"31042280","title":"Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence.","journal":"JAMA psychiatry"},{"date":"2016","pmid":"26655867","title":"PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies.","journal":"Neuro-degenerative diseases"},{"date":"2015","pmid":"26137443","title":"Putamen-midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases.","journal":"NeuroImage. Clinical"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"ALTROPANE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ALTROPANE is a small molecule drug in the altropane class, developed by an unknown original developer and currently owned by an unknown entity. Its target and exact mechanism of action are not specified. ALTROPANE is not FDA-approved for any indications, and its commercial status, patent status, and availability of generic manufacturers are unknown. Key safety considerations are not available due to the lack of FDA approval. Further research is needed to understand the pharmacology and clinical utility of ALTROPANE.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:40:51.874927+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}