{"id":"altizide","rwe":[],"tags":[{"label":"altizide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C03EA04","category":"atc"},{"label":"Active","category":"status"},{"label":"Edema","category":"indication"},{"label":"Hypertensive disorder","category":"indication"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:30:49.139505","allNames":"altizid","offLabel":[],"synonyms":["altizide","aldactazine","althiazide","althizide","altizid","racemic althiazide","altizida"],"timeline":[],"brandName":"Altizid","ecosystem":[{"indication":"Edema","otherDrugs":[{"name":"acetazolamide","slug":"acetazolamide","company":"Teva Branded Pharm"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"bumetanide","slug":"bumetanide","company":""},{"name":"chlorothiazide","slug":"chlorothiazide","company":"Oak Pharms Akorn"}],"globalPrevalence":200000},{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"altizide","explanation":"Think of it like a sponge: when you squeeze a sponge, water comes out. Altizide helps the kidneys squeeze out excess water and salt by blocking the tiny tubes where they're reabsorbed, allowing more fluid to be excreted in the urine.","oneSentence":"Altizide works by inhibiting the reabsorption of sodium and chloride in the kidneys.","technicalDetail":"Altizide acts as a thiazide-like diuretic, inhibiting the sodium-chloride cotransporter in the distal convoluted tubule of the nephron, leading to increased sodium and chloride excretion and subsequent diuresis."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Altizide","title":"Altizide","extract":"Altizide is a thiazide diuretic. In combination with spironolactone it is sold under the brand name of Aldactacine and Aldactazine by Pfizer and other names by other companies."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/140","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=altizide","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Altizide","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:38:45.978992","biosimilars":[],"competitors":[{"drugName":"hydrochlorothiazide","drugSlug":"hydrochlorothiazide","fdaApproval":"1959-02-12","patentExpiry":"Jan 23, 2044","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"trichlormethiazide","drugSlug":"trichlormethiazide","fdaApproval":"1960-03-09","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"chlortalidone","drugSlug":"chlortalidone","fdaApproval":"1960-04-07","relationship":"same-class"},{"drugName":"metolazone","drugSlug":"metolazone","fdaApproval":"1973-11-27","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"bendroflumethiazide","drugSlug":"bendroflumethiazide","fdaApproval":"1959-12-07","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"altizide","indications":{"approved":[{"name":"Edema","source":"DrugCentral","snomedId":267038008,"regulator":"FDA","usPrevalence":null,"globalPrevalence":200000,"prevalenceMethod":"curated","prevalenceSource":"Int Arch Allergy Immunol, 2025 (PMID:39827848)"},{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(20)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"hydrochlorothiazide","brandName":"hydrochlorothiazide","genericName":"hydrochlorothiazide","approvalYear":"1959","relationship":"same-class"},{"drugId":"trichlormethiazide","brandName":"trichlormethiazide","genericName":"trichlormethiazide","approvalYear":"1960","relationship":"same-class"},{"drugId":"chlortalidone","brandName":"chlortalidone","genericName":"chlortalidone","approvalYear":"1960","relationship":"same-class"},{"drugId":"metolazone","brandName":"metolazone","genericName":"metolazone","approvalYear":"1973","relationship":"same-class"},{"drugId":"bendroflumethiazide","brandName":"bendroflumethiazide","genericName":"bendroflumethiazide","approvalYear":"1959","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005226","UNII":"GI8CB72B0D","CHEBI":"CHEBI:91768","INN_ID":"1382","RXNORM":"17599","UMLSCUI":"C0051500","ChEMBL_ID":"CHEMBL599870","KEGG_DRUG":"D02838","PUBCHEM_CID":"2122","SNOMEDCT_US":"717101002","MESH_SUPPLEMENTAL_RECORD_UI":"C006480"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":20,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"C03EA04","allCodes":["C03EA04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2021 Feb","pmid":"33150508","title":"Transcriptomic analysis of key genes and pathways in human bronchial epithelial cells BEAS-2B exposed to urban particulate matter.","journal":"Environmental science and pollution research international"},{"date":"2009 Mar 20","pmid":"19187939","title":"Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis.","journal":"Journal of chromatography. A"},{"date":"2009 Feb 20","pmid":"19108977","title":"Stability of selected chlorinated thiazide diuretics.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1998","pmid":"9922803","title":"Effects of spironolactone-altizide on left ventricular hypertrophy.","journal":"Acta cardiologica"},{"date":"1997 May-Jun","pmid":"9366100","title":"The Eurevie Study: contrasting effect of piretanide and thiazides in mild to moderate hypertension.","journal":"Therapie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Altizide is a small molecule thiazide diuretic. It is sold under various brand names, including Aldactacine and Aldactazine, often in combination with spironolactone.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}