{"id":"alteplase-dwell-arm","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Bleeding (intracranial, gastrointestinal, or other sites)"},{"rate":"5-10","effect":"Reperfusion arrhythmias"},{"rate":"5-10","effect":"Hypotension"},{"rate":"<1","effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL1201593","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alteplase is a recombinant tissue plasminogen activator that directly activates fibrinolysis by converting plasminogen to plasmin, which degrades fibrin in blood clots. The 'dwell arm' formulation refers to a specific administration protocol where the drug dwells in a catheter or treatment area, commonly used in catheter-directed thrombolysis for peripheral arterial or venous occlusions. This localized delivery approach aims to maximize clot dissolution while minimizing systemic exposure.","oneSentence":"Alteplase is a tissue plasminogen activator (tPA) that converts plasminogen to plasmin to dissolve blood clots.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:17:12.921Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute ischemic stroke"},{"name":"Acute myocardial infarction"},{"name":"Pulmonary embolism"},{"name":"Peripheral arterial or venous thrombosis (catheter-directed thrombolysis)"}]},"trialDetails":[{"nctId":"NCT01478698","phase":"PHASE1","title":"The Safety and Tolerability of Intra-abdominal t-PA and DNase on Peritonitis in Peritoneal Dialysis Patients","status":"TERMINATED","sponsor":"Sir Charles Gairdner Hospital","startDate":"2016-01-01","conditions":"Peritoneal Dialysis, Peritoneal Dialysis, Continuous Ambulatory","enrollment":5},{"nctId":"NCT00417768","phase":"PHASE2, PHASE3","title":"Safety and Effectiveness of tPA in Intra-abdominal Abscesses","status":"TERMINATED","sponsor":"University Health Network, Toronto","startDate":"2005-07","conditions":"Abscess","enrollment":35},{"nctId":"NCT00303420","phase":"PHASE4","title":"Alteplase for Blood Flow Restoration in Hemodialysis Catheters","status":"TERMINATED","sponsor":"University of Manitoba","startDate":"2004-09","conditions":"Thrombosis","enrollment":180}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cathflo","alteplase","rTPA"],"phase":"marketed","status":"active","brandName":"alteplase dwell arm","genericName":"alteplase dwell arm","companyName":"University of Manitoba","companyId":"university-of-manitoba","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alteplase is a tissue plasminogen activator (tPA) that converts plasminogen to plasmin to dissolve blood clots. Used for Acute ischemic stroke, Acute myocardial infarction, Pulmonary embolism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}