{"id":"altabax-r","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site irritation"},{"rate":null,"effect":"Application site pruritus"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL89731","moleculeType":"Small molecule","molecularWeight":"159.14"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Retapamulin is a pleuromutilin antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is bacteriostatic, meaning it stops bacterial growth rather than directly killing bacteria. This mechanism makes it effective against gram-positive bacteria commonly responsible for skin infections.","oneSentence":"Retapamulin is a bacterial protein synthesis inhibitor that binds to the bacterial ribosome to prevent bacterial growth.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:12.937Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Impetigo caused by susceptible strains of Staphylococcus aureus or Streptococcus pyogenes"}]},"trialDetails":[{"nctId":"NCT00871208","phase":"PHASE4","title":"Trial of Treatment of Atopic Dermatitis With Concurrent Altabax® and Topical Low-Potency Corticosteroids Versus Low-Potency Corticosteroid Mono-therapy","status":"WITHDRAWN","sponsor":"St. Luke's-Roosevelt Hospital Center","startDate":"2009-05","conditions":"Atopic Dermatitis","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Altabax(R)ointment","Locoid lipocream (R)"],"phase":"marketed","status":"active","brandName":"Altabax (R)","genericName":"Altabax (R)","companyName":"St. Luke's-Roosevelt Hospital Center","companyId":"st-luke-s-roosevelt-hospital-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Retapamulin is a bacterial protein synthesis inhibitor that binds to the bacterial ribosome to prevent bacterial growth. Used for Impetigo caused by susceptible strains of Staphylococcus aureus or Streptococcus pyogenes.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}