{"id":"alsactide","rwe":[{"pmid":"2853038","year":"1988","title":"Effects of exogenous melatonin on human pituitary and adrenal secretions. Hormonal responses to specific stimuli after acute administration of different doses at two opposite circadian stages in men.","finding":"","journal":"Chronobiologia","studyType":"Clinical Study"},{"pmid":"2850604","year":"1988","title":"Plasma steroid responses to circadian-stage-specified injection of different doses of the ACTH analogue alsactide (ACTH 1-17) in healthy adult human males.","finding":"","journal":"La Ricerca in clinica e in laboratorio","studyType":"Clinical Study"},{"pmid":"2828458","year":"1987","title":"Acute administration of melatonin at two opposite circadian stages does not change responses to gonadotropin releasing hormone, thyrotropin releasing hormone and ACTH in healthy adult males.","finding":"","journal":"Journal of endocrinological investigation","studyType":"Clinical Study"},{"pmid":"3040344","year":"1987","title":"Alsactide: ACTH-agonist for use in microdoses in brain-adrenal and other feedsidewards.","finding":"","journal":"Chronobiologia","studyType":"Clinical Study"},{"pmid":"3023113","year":"1986","title":"Alpha-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"alsactide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"V04CH04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"synchrodyn","offLabel":[],"synonyms":["alsactide","synchrodyn"],"timeline":[],"brandName":"Synchrodyn","ecosystem":[],"mechanism":{"modality":"Peptide","drugClass":"alsactide","explanation":"Imagine Synchrodyn as a key that fits into a lock on a cell's surface. When it binds, it can either turn the lock to open up a new pathway for helpful molecules to enter the cell or block the lock to prevent harmful molecules from entering. This can help to restore balance and promote healing in the body.","oneSentence":"Synchrodyn works by binding to specific receptors or enzymes to modulate their activity and produce a therapeutic effect.","technicalDetail":"Synchrodyn's mechanism of action involves the interaction with specific receptors or enzymes, which can modulate signaling pathways and influence various cellular processes."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Alsactide","title":"Alsactide","extract":"Alsactide (INN; brand name Synchrodyn 1-17 or simply Synchrodyn; former development code Hoechst 433; also known as alisactide) is a synthetic peptide and analogue of adrenocorticotropic hormone (ACTH) which is used in Italy as a diagnostic agent in kidney function for adrenal insufficiency. Like ACTH, alsactide is thought to act as a non-selective agonist of the melanocortin receptors, including the ACTH receptor (MC2R). However, it appears to show a different profile of receptor selectivity relative to ACTH, as it apparently demonstrated no evidence of inhibition of endogenous ACTH in Addison's disease patients."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/139","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALSACTIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Alsactide","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:38:46.723946","biosimilars":[],"competitors":[{"drugName":"inulin","drugSlug":"inulin","fdaApproval":"1940-04-30","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"indigo carmine","drugSlug":"indigo-carmine","fdaApproval":"2022-07-08","relationship":"same-class"},{"drugName":"aminohippuric acid","drugSlug":"aminohippuric-acid","fdaApproval":"1944-12-30","relationship":"same-class"}],"genericName":"alsactide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"inulin","brandName":"inulin","genericName":"inulin","approvalYear":"1940","relationship":"same-class"},{"drugId":"indigo-carmine","brandName":"indigo carmine","genericName":"indigo carmine","approvalYear":"2022","relationship":"same-class"},{"drugId":"aminohippuric-acid","brandName":"aminohippuric acid","genericName":"aminohippuric acid","approvalYear":"1944","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"J0K70H3420","CHEBI":"CHEBI:135911","INN_ID":"4965","UMLSCUI":"C0050622","ChEMBL_ID":"CHEMBL3989434","KEGG_DRUG":"D07417","DRUGBANK_ID":"DB13298","MESH_SUPPLEMENTAL_RECORD_UI":"C028238"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"V04CH04","allCodes":["V04CH04"]},"biosimilarFilings":[],"recentPublications":[{"date":"1988 Oct-Dec","pmid":"2853038","title":"Effects of exogenous melatonin on human pituitary and adrenal secretions. Hormonal responses to specific stimuli after acute administration of different doses at two opposite circadian stages in men.","journal":"Chronobiologia"},{"date":"1988 Apr-Sep","pmid":"2850604","title":"Plasma steroid responses to circadian-stage-specified injection of different doses of the ACTH analogue alsactide (ACTH 1-17) in healthy adult human males.","journal":"La Ricerca in clinica e in laboratorio"},{"date":"1987 Oct","pmid":"2828458","title":"Acute administration of melatonin at two opposite circadian stages does not change responses to gonadotropin releasing hormone, thyrotropin releasing hormone and ACTH in healthy adult males.","journal":"Journal of endocrinological investigation"},{"date":"1987 Apr-Jun","pmid":"3040344","title":"Alsactide: ACTH-agonist for use in microdoses in brain-adrenal and other feedsidewards.","journal":"Chronobiologia"},{"date":"1986 Oct 14","pmid":"3023113","title":"Alpha-MSH and other ACTH fragments improve cardiovascular function and survival in experimental hemorrhagic shock.","journal":"European journal of pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Recombinant protein","firstApprovalDate":"","aiSummary":"Synchrodyn is a protein modality. It is also known by the synonyms ALSACTIDA, ALSACTIDE, HOE-433, and ALSACTIDE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}