{"id":"alprostadil-alfadex","rwe":[],"tags":[{"label":"Prostaglandin Analog","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Platelet Aggregation Inhibitors","category":"pharmacology"},{"label":"Urological Agents","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tandetoron","offLabel":[],"synonyms":["alprostadil alfadex","tandetoron"],"timeline":[],"brandName":"Tandetoron","ecosystem":[],"mechanism":{"moaClass":"Prostaglandin Receptor Agonists","modality":"Small Molecule","drugClass":"Prostaglandin Analog","explanation":"Think of prostaglandins like messengers that help blood vessels relax and improve blood flow. Tandetoron sends a similar message to the body, helping to widen blood vessels and improve blood flow to specific areas. This can be helpful for conditions where blood flow is a problem.","oneSentence":"Tandetoron works by binding to and activating prostaglandin receptors in the body, mimicking the natural prostaglandin prostaglandin E1.","technicalDetail":"Tandetoron, a prostaglandin E1 analog, exerts its effects by binding to EP receptors, specifically EP1, EP2, EP3, and EP4, leading to vasodilation and increased blood flow."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Prostaglandin_E1","title":"Prostaglandin E1","extract":"Prostaglandin E1 (PGE1) is a naturally occurring prostaglandin with various medical uses. Alprostadil and misoprostol are synthetic forms of prostaglandin E1 used as medications. Lubiprostone, a derivative of prostaglandin E1, is also used as a medication. Prostaglandin E1 is a vasodilator. It has various effects in the body that include opening blood vessels, relaxing smooth muscle, inhibiting clotting, and causing uterine contractions."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3864","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=alprostadil alfadex","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Prostaglandin_E1","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:38:38.898434","biosimilars":[],"competitors":[],"genericName":"alprostadil alfadex","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"11600","NDDF":"000704","CHEBI":"CHEBI:34532","VANDF":"4018099","INN_ID":"4425","RXNORM":"598","UMLSCUI":"C0002335","ChEMBL_ID":"CHEMBL2108900","KEGG_DRUG":"D02705","DRUGBANK_ID":"DB00770","PUBCHEM_CID":"5282234","SNOMEDCT_US":"109119001","MESH_DESCRIPTOR_UI":"D000527"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Tandetoron (alprostadil alfadex) is a prostaglandin analog, a small molecule drug that works by mimicking the effects of a natural prostaglandin in the body. It is used to treat certain conditions, although its specific indications are not provided. The commercial status of Tandetoron is unknown, and it may be patented or have generic manufacturers. Key safety considerations are not specified. Further information is needed to provide a comprehensive summary.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}