{"id":"alprax-alprazolam","safety":{"commonSideEffects":[{"rate":"25-50","effect":"Drowsiness"},{"rate":"15-30","effect":"Dizziness"},{"rate":"10-20","effect":"Fatigue"},{"rate":"10-15","effect":"Cognitive impairment"},{"rate":null,"effect":"Dependence/withdrawal risk"},{"rate":"5-10","effect":"Ataxia"}]},"_chembl":{"chemblId":"CHEMBL661","moleculeType":"Small molecule","molecularWeight":"308.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alprazolam is a benzodiazepine that binds to GABA-A receptors, which are ligand-gated chloride channels. By potentiating GABA's action, it increases chloride ion influx into neurons, hyperpolarizing the cell membrane and reducing the likelihood of action potential firing. This results in decreased anxiety, muscle relaxation, and sedation.","oneSentence":"Alprazolam enhances the inhibitory effects of GABA at the GABA-A receptor in the central nervous system, reducing neuronal excitability and producing anxiolytic and sedative effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:34.865Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anxiety disorders"},{"name":"Panic disorder"},{"name":"Generalized anxiety disorder"}]},"trialDetails":[{"nctId":"NCT01486615","phase":"PHASE4","title":"Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone","status":"COMPLETED","sponsor":"B.P. Koirala Institute of Health Sciences","startDate":"2011-10","conditions":"Anxiety","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"(alprax) alprazolam","genericName":"(alprax) alprazolam","companyName":"B.P. Koirala Institute of Health Sciences","companyId":"b-p-koirala-institute-of-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alprazolam enhances the inhibitory effects of GABA at the GABA-A receptor, reducing neuronal excitability and producing anxiolytic and sedative effects. Used for Anxiety disorder, Panic disorder, Generalized anxiety disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}