{"id":"alphaprodine","rwe":[],"tags":[{"label":"alphaprodine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Opioid","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Narcotics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[],"contraindications":["Acute abdominal pain","Alcohol intoxication","Alcohol withdrawal delirium","Asthenia","Benign intracranial hypertension","Benign prostatic hyperplasia","Bradycardia","Central nervous system depression","Coma","Conduction disorder of the heart","Constipation","Cor pulmonale","Decreased respiratory function","Dehydration","Dependent drug abuse","Disease of liver","Disorder of gallbladder","Drug-induced psychosis","Dysfunction of sphincter of Oddi","Exacerbation of asthma","Hypercapnia","Hypothyroidism","Hypoxia","Inflammatory bowel disease","Injury of head","Kidney disease","Lesion of brain","Low blood pressure","Mood swings","Morbid obesity","Neoplasm of brain","Operation on gastrointestinal tract","Primary adrenocortical insufficiency","Pulmonary emphysema","Retention of urine","Seizure disorder","Shock","Substance abuse","Suicidal thoughts","Ulcerative colitis","Urethral stricture"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"nisintil","offLabel":[],"synonyms":["alphaprodine","(+/-)-Alphaprodine","nisintil","prisilidin","dl-alpha-Prodine"],"timeline":[],"brandName":"Nisintil","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"alphaprodine","explanation":"Imagine your brain has special locks for pain signals. Nisintil is a key that fits into these locks, reducing the pain signal and making you feel better. This is similar to how other opioid medications work, but nisintil's exact mechanism is not fully understood.","oneSentence":"Nisintil works by binding to opioid receptors in the brain, altering the perception of and response to pain.","technicalDetail":"Nisintil exerts its effects by binding to mu-opioid receptors, which are involved in the transmission of pain signals in the central nervous system."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/132","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALPHAPRODINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:38:26.751942","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"alphaprodine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000147694","NDDF":"004621","UNII":"001O2254AC","VUID":"4019598","CHEBI":"CHEBI:135075","VANDF":"4019598","INN_ID":"1063","RXNORM":"594","UMLSCUI":"C0002327","ChEMBL_ID":"CHEMBL1623765","DRUGBANK_ID":"DB13160","PUBCHEM_CID":"6471","SNOMEDCT_US":"52885008","MESH_DESCRIPTOR_UI":"D000522"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":78,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nisintil is a small molecule with the synonyms ALPHAPRODINE HCL, ALPHAPRODINE HYDROCHLORIDE, and ALPHAPRODINE HYDROCHLORIDE CII. It is also known as NU 1196.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}