{"id":"alphacalcidol","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"trials":[],"_chembl":null,"aliases":[],"patents":[],"pricing":[],"offLabel":[],"timeline":[],"_dailymed":null,"ecosystem":[],"mechanism":{"target":"Sodium-dependent noradrenaline transporter, Vitamin D3 receptor"},"_scrapedAt":"2026-03-28T04:08:26.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"references":[],"biosimilars":[],"competitors":[],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"indications":{"approved":[{"name":"Hyperparathyroidism","diseaseId":"hyperparathyroidism","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Hypoparathyroidism","diseaseId":"hypoparathyroidism","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Neonatal hypocalcemia","diseaseId":"neonatal-hypocalcemia","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Renal osteodystrophy","diseaseId":"renal-osteodystrophy","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07455656","phase":"NA","title":"Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction","status":"RECRUITING","sponsor":"Al-Azhar University","startDate":"2025-08-01","conditions":"Malocclusions, Canine Retraction","enrollment":16},{"nctId":"NCT07381998","phase":"NA","title":"Effects of Total Thyroid Removal on Parathyroid Function and Quality of Life","status":"ENROLLING_BY_INVITATION","sponsor":"Aarhus University Hospital","startDate":"2026-01-01","conditions":"Hypoparathyroidism Post-surgical, Quality of Life","enrollment":150},{"nctId":"NCT07315139","phase":"NA","title":"Pentoxifylline on Inflammatory Markers in Non-Diabetic Chronic Kidney Disease Patients","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-02-01","conditions":"Pentoxifylline, Inflammatory Markers, Non-Diabetic","enrollment":42},{"nctId":"NCT05680818","phase":"PHASE3","title":"Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1","status":"ACTIVE_NOT_RECRUITING","sponsor":"Calcilytix Therapeutics, Inc., a BridgeBio company","startDate":"2023-01-06","conditions":"Autosomal Dominant Hypocalcemia (ADH)","enrollment":67},{"nctId":"NCT03210688","phase":"PHASE4","title":"Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy","status":"COMPLETED","sponsor":"University of Aarhus","startDate":"2018-05-01","conditions":"Minimal Change Disease, Nephrotic Syndrome","enrollment":71},{"nctId":"NCT03582917","phase":"PHASE2","title":"The Role of VitD in Rehabilitation of Idiopathic Adolescent Scoliosis","status":"RECRUITING","sponsor":"University of Ioannina","startDate":"2018-09-20","conditions":"Scoliosis; Adolescence","enrollment":80},{"nctId":"NCT06571344","phase":"","title":"Vitamin D in Dialysis Patients - Diagnostic and Therapeutic Management","status":"RECRUITING","sponsor":"Medical University of Gdansk","startDate":"2022-11-01","conditions":"Vitamin D Deficiency Due to Chronic Kidney Disease","enrollment":160},{"nctId":"NCT06385093","phase":"PHASE4","title":"A Study on the Prevention and Treatment of GIOP With Eldecalcitol","status":"NOT_YET_RECRUITING","sponsor":"Chinese SLE Treatment And Research Group","startDate":"2024-06","conditions":"Rheumatoid Arthritis, Osteoporosis, Osteopenia","enrollment":314},{"nctId":"NCT06272227","phase":"PHASE4","title":"Effect of Alfacalcidol on Muscle Function in Osteoporosis Patients","status":"UNKNOWN","sponsor":"Yonsei University","startDate":"2024-02-13","conditions":"Sarcopenia","enrollment":340},{"nctId":"NCT04967469","phase":"NA","title":"Comparison of Serum Calcium Level Between Preoperative Vitamin D and Non-vitamin D Regimen of Total Parathyroidectomy in End-stage Renal Failure Patients in Rajavithi Hospital","status":"COMPLETED","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2020-09-01","conditions":"End Stage Renal Disease","enrollment":60},{"nctId":"NCT06016400","phase":"PHASE2, PHASE3","title":"Using Vitamin D to Reduce Oral Mucosal Inflammation in Chemotherapy Patients With Oral Squamous Cell Carcinoma","status":"UNKNOWN","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2021-06-14","conditions":"Oral Squamous Cell Carcinoma, Oral Mucositis","enrollment":412},{"nctId":"NCT04750460","phase":"PHASE3","title":"Injection of Teriparatide to Prevent Hypocalcemia After Parathyroidectomy in Dialysis Patients (TeriCa).","status":"COMPLETED","sponsor":"Saint Petersburg State University, Russia","startDate":"2021-03-01","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease-Mineral and Bone Disorder, Dialysis","enrollment":20},{"nctId":"NCT05505253","phase":"PHASE3","title":"Alfacalcidol Supplementation on Levator Ani Muscle Strength of Menopausal Pelvic Organ Prolapse Patients","status":"COMPLETED","sponsor":"Universitas Padjadjaran","startDate":"2020-11-01","conditions":"Pelvic Organ Prolapse","enrollment":48},{"nctId":"NCT02306187","phase":"PHASE1","title":"The Effectiveness of Eldecalcitol in the Bisphosphonate Non-respondered-patients With Osteoporosis","status":"UNKNOWN","sponsor":"Shinshu University","startDate":"2014-12","conditions":"Osteoporosis","enrollment":100},{"nctId":"NCT03183557","phase":"PHASE2","title":"Efficacy of Zoledronic Acid in Osteoporosis","status":"UNKNOWN","sponsor":"Shinshu University","startDate":"2017-10-12","conditions":"Osteoporosis","enrollment":100},{"nctId":"NCT02824718","phase":"PHASE2","title":"Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2017-06-06","conditions":"Autosomal Dominant Hypocalcemia OR Primary Hypoparathyroidism Related to Other Cause But Complicated by Hypercalciuria Under Treatment","enrollment":16},{"nctId":"NCT04166253","phase":"PHASE2","title":"Protective Role of Vitamin D in Breast Cancer Patients Treated With Doxorubicin","status":"COMPLETED","sponsor":"Damanhour University","startDate":"2019-09-01","conditions":"Breast Cancer","enrollment":100},{"nctId":"NCT03182699","phase":"PHASE4","title":"Effect of Etelcalcetide on Cardiac Hypertrophy in Hemodialysis Patients","status":"COMPLETED","sponsor":"Rainer Oberbauer","startDate":"2017-10-01","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease Requiring Chronic Dialysis, Left Ventricular Hypertrophy","enrollment":62},{"nctId":"NCT04405960","phase":"PHASE3","title":"Role of Alphacalcidol Supplement to Reduce Pain and COMP in Geriatric Knee Osteoarthritis Patients","status":"COMPLETED","sponsor":"Syarif Hidayatullah State Islamic University Jakarta","startDate":"2017-07-01","conditions":"Osteoarthritis, Knee, Aged","enrollment":146},{"nctId":"NCT02993302","phase":"PHASE2","title":"Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients","status":"COMPLETED","sponsor":"Dr Cipto Mangunkusumo General Hospital","startDate":"2014-07","conditions":"Graves Disease","enrollment":25},{"nctId":"NCT04146259","phase":"","title":"Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism","status":"COMPLETED","sponsor":"University of Athens","startDate":"2017-01-01","conditions":"Hypoparathyroidism Postprocedural","enrollment":109},{"nctId":"NCT03147677","phase":"PHASE4","title":"Clinical Study of Treating Type 2 Diabetic Nephropathy With Alfacalcidol and Irbesartan","status":"COMPLETED","sponsor":"The Third Xiangya Hospital of Central South University","startDate":"2016-07-28","conditions":"Type 2 Diabetic Nephropathy","enrollment":60},{"nctId":"NCT04085770","phase":"PHASE4","title":"Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2017-04-01","conditions":"Cardiac Valve Replacement Complication","enrollment":86},{"nctId":"NCT03777033","phase":"NA","title":"Systematic Administration of Calcium and Vitamin D After Thyroidectomy","status":"UNKNOWN","sponsor":"Hellenic Red Cross Hospital","startDate":"2015-03-01","conditions":"Thyroid Diseases","enrollment":160},{"nctId":"NCT01181531","phase":"PHASE4","title":"Compare the Efficacy of Cinacalcet vs Traditional Vitamin D for Secondary Hyperparathyroidism (SHPT) Among Subjects Undergoing Hemodialysis","status":"COMPLETED","sponsor":"Amgen","startDate":"2010-10-01","conditions":"Hyperparathyroidism, Secondary","enrollment":312},{"nctId":"NCT01656512","phase":"PHASE3","title":"Zometa Study in Pediatric Acute Lymphoblastic Leukemia","status":"COMPLETED","sponsor":"Children's Cancer Hospital Egypt 57357","startDate":"2011-10","conditions":"Osteoporosis","enrollment":95},{"nctId":"NCT03496246","phase":"NA","title":"Vitamin D Status in Inflammatory Bowel Disease","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2018-04","conditions":"Vitamin D Deficiency, Inflammatory Bowel Diseases","enrollment":50},{"nctId":"NCT03292744","phase":"PHASE4","title":"Effect of Alfacalcidol to Respiratory Infection and Immune Response of Indonesian Elderly","status":"UNKNOWN","sponsor":"Indonesia University","startDate":"2017-01-10","conditions":"Frail Elderly Syndrome, Elderly Infection","enrollment":110},{"nctId":"NCT02895061","phase":"NA","title":"Effectiveness of Oral Alfacalcidol for Secondary Hyperparathyroidism in Chronic Hemodialysis Patients.","status":"COMPLETED","sponsor":"Phramongkutklao College of Medicine and Hospital","startDate":"2015-01","conditions":"Alfacalcidol, Secondary Hyperparathyroidism, Hemodialysis","enrollment":502},{"nctId":"NCT01057186","phase":"","title":"Hypophosphatemic Rickets in Norway","status":"UNKNOWN","sponsor":"Haukeland University Hospital","startDate":"2009-12","conditions":"Hypophosphatemia, Familial, Rickets, Hyperphosphatemia","enrollment":80},{"nctId":"NCT01774812","phase":"PHASE2","title":"Vitamin D and Cardiac Autonomic Tone in Hemodialysis","status":"COMPLETED","sponsor":"University of Calgary","startDate":"2013-01","conditions":"Cardiovascular Disease, Sudden Cardiac Death","enrollment":56},{"nctId":"NCT02747381","phase":"PHASE4","title":"The Effect of Vitamin D Supplementation on the Pulmonary Functions of Adult Asthmatic Egyptian Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2014-08","conditions":"Asthma","enrollment":82},{"nctId":"NCT00828347","phase":"NA","title":"Maintenance Vitamin D Therapy for Secondary Hyperparathyroidism (2HPT)","status":"COMPLETED","sponsor":"Kumamoto University","startDate":"2008-01","conditions":"Secondary Hyperparathyroidism","enrollment":35},{"nctId":"NCT02327091","phase":"PHASE3","title":"The Effect of Alfacalcidol on Muscle Strength in Elderly Indonesian Women : A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2012-04","conditions":"Muscle Weakness","enrollment":122},{"nctId":"NCT01974167","phase":"NA","title":"Eldecalcitol for GLucocorticoid Induced OsteopoRosIs Versus Alfacalcidol","status":"UNKNOWN","sponsor":"e-GLORIA trial Protocol Review Committee","startDate":"2013-12","conditions":"Osteoporosis","enrollment":400},{"nctId":"NCT00165698","phase":"PHASE3","title":"Efficacy and Safety Study on Menatetrenone in the Treatment of Postmenopausal Osteoporosis Women","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2005-05","conditions":"Postmenopausal Osteoporosis","enrollment":240},{"nctId":"NCT00144456","phase":"PHASE3","title":"A New Active Vitamin D, ED-71 for Osteoporosis","status":"COMPLETED","sponsor":"Chugai Pharmaceutical","startDate":"2004-09","conditions":"Osteoporosis","enrollment":1056},{"nctId":"NCT01896609","phase":"PHASE4","title":"Trial Comparing the Efficacy, Tolerability and Safety Between Three Arms in Treatment of HCV in Egyptian Population","status":"UNKNOWN","sponsor":"MinaPharm Pharmaceuticals","startDate":"2013-06","conditions":"Chronic Hepatitis c","enrollment":300},{"nctId":"NCT01765010","phase":"PHASE4","title":"The Effect of Inactive and Active Vitamin D on Serum Sclerostin/dickkopf1 Levels","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2013-01","conditions":"Osteoporosis","enrollment":88},{"nctId":"NCT01752244","phase":"NA","title":"Assessing the Effects of Alfacalcidol Intake on Expression of Involed Gene in Metabolism in Obese Subjects","status":"UNKNOWN","sponsor":"Tehran University of Medical Sciences","startDate":"2012-01","conditions":"Obesity","enrollment":94},{"nctId":"NCT01231438","phase":"PHASE2","title":"Treatment of Early Stage Renal Failure With Active Vitamin D or a Phosphate Binder.","status":"COMPLETED","sponsor":"Helse Stavanger HF","startDate":"2010-10","conditions":"Kidney Failure","enrollment":21},{"nctId":"NCT00977080","phase":"PHASE4","title":"Evaluation of the Effectiveness of Paricalcitol Versus Cinacalcet With Low-Dose Vitamin D","status":"COMPLETED","sponsor":"Abbott","startDate":"2009-11","conditions":"Chronic Kidney Disease, Secondary Hyperparathyroidism, Hemodialysis","enrollment":272},{"nctId":"NCT00668330","phase":"PHASE4","title":"Steroid Induced Osteoporosis in Patients With Systemic Lupus Erythematosus","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2007-04","conditions":"Systemic Lupus Erythematosus","enrollment":40},{"nctId":"NCT01084538","phase":"","title":"Study of Zemplar iv in Patients With End Stage Chronic Kidney Disease, Undergoing Haemodialysis","status":"COMPLETED","sponsor":"Abbott","startDate":"2007-09","conditions":"Parathyroid Hormone","enrollment":181},{"nctId":"NCT00483275","phase":"PHASE4","title":"Fall Prevention by Alfacalcidol and Training","status":"WITHDRAWN","sponsor":"Ruhr University of Bochum","startDate":"2007-06","conditions":"Accidental Falls, Chronic Renal Insufficiency, Aged","enrollment":484},{"nctId":"NCT01364688","phase":"PHASE2","title":"Oral Alfacalcidol and Coronary Artery Calcification in Predialysis Chronic Kidney Disease","status":"UNKNOWN","sponsor":"Ramathibodi Hospital","startDate":"2011-05","conditions":"Vascular Calcification","enrollment":80},{"nctId":"NCT00469599","phase":"NA","title":"Treatment of Secondary Hyperparathyroidism in the Uremic Patient","status":"TERMINATED","sponsor":"Zealand University Hospital","startDate":"2007-07","conditions":"Secondary Hyperparathyroidism, Chronic Kidney Disease, Vitamin D Deficiency","enrollment":86},{"nctId":"NCT01115543","phase":"PHASE4","title":"Efficacy and Safety of Alfacalcidol Compared to Calcitriol for Treatment of Secondary Hyperparathyroidism","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2008-08","conditions":"Secondary Hyperparathyroidism, End Stage Renal Disease","enrollment":32},{"nctId":"NCT01020253","phase":"NA","title":"The Effectiveness of Two Osteoporosis Drugs on Prosthetic Bone Mineral Density (BMD) Loss After Total Hip Arthroplasty(THA)","status":"UNKNOWN","sponsor":"Yokohama City University Medical Center","startDate":"2006-01","conditions":"Bone Density, Arthroplasty, Replacement, Hip","enrollment":60},{"nctId":"NCT00168909","phase":"PHASE4","title":"Influence of Alfacalcidol on Falls in Osteopenic/Osteoporotic Postmenopausal Women (ALFA Study)","status":"COMPLETED","sponsor":"Charite University, Berlin, Germany","startDate":"2003-06","conditions":"Osteoporosis, Postmenopausal, Osteopenia, Falls","enrollment":282},{"nctId":"NCT00630214","phase":"PHASE2","title":"Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2004-05","conditions":"Hypocalcemia","enrollment":200},{"nctId":"NCT00138983","phase":"PHASE3","title":"Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol.","status":"COMPLETED","sponsor":"UMC Utrecht","startDate":"2000-05","conditions":"Rheumatoid Arthritis, Polymyalgia Rheumatica, Giant Cell Arteritis","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"formularyStatus":[],"_approvalHistory":[],"developmentCodes":[],"ownershipHistory":[],"publicationCount":126,"therapeuticAreas":["Nephrology"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"phase_2","status":"active","brandName":"Alphacalcidol","genericName":"Alphacalcidol","companyName":"University of Ioannina","companyId":"university-of-ioannina","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alfacalcidol is a small molecule that acts as a vitamin D receptor agonist, specifically targeting the vitamin D3 receptor. It is used for supplementation in humans and has been studied in clinical trials for various conditions, including osteoporosis, rheumatoid arthritis, and sarcopenia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}