{"id":"alpha-methyldopa","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Sedation/drowsiness"},{"rate":"5-10","effect":"Dry mouth"},{"rate":"5-10","effect":"Fatigue"},{"rate":"5","effect":"Headache"},{"rate":"5-10","effect":"Dizziness"},{"rate":"0.1-0.2","effect":"Hemolytic anemia"},{"rate":"0.1-0.2","effect":"Hepatotoxicity"}]},"_chembl":{"chemblId":"CHEMBL459","moleculeType":"Small molecule","molecularWeight":"211.22"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alpha methyldopa crosses the blood-brain barrier and is metabolized to alpha-methylnorepinephrine in the central nervous system. This active metabolite stimulates alpha-2 adrenergic receptors in the brainstem, decreasing sympathetic nervous system activity and reducing peripheral vascular resistance, thereby lowering blood pressure. It also has some peripheral alpha-adrenergic activity.","oneSentence":"Alpha methyldopa is a prodrug that is converted to alpha-methylnorepinephrine, which acts as a central-acting alpha-2 adrenergic agonist to reduce sympathetic outflow and lower blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:20.420Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Hypertension in pregnancy"}]},"trialDetails":[{"nctId":"NCT04246437","phase":"PHASE1","title":"[18F]F-DOPA Imaging in Patients With Autonomic Failure","status":"RECRUITING","sponsor":"Daniel Claassen","startDate":"2020-02-04","conditions":"Autonomic Failure, Pure Autonomic Failure, Parkinson Disease","enrollment":40},{"nctId":"NCT07151378","phase":"PHASE3","title":"Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease","status":"RECRUITING","sponsor":"University Hospital Tuebingen","startDate":"2025-10-27","conditions":"PARKINSON DISEASE (Disorder)","enrollment":150},{"nctId":"NCT07442591","phase":"PHASE1","title":"A Study to Assess Effect of Dosing Intervals on Multiple-Dose Pharmacokinetics of WD-1603 Taken Before Meals in Healthy Participants","status":"NOT_YET_RECRUITING","sponsor":"Shanghai WD Pharmaceutical Co., Ltd.","startDate":"2026-03","conditions":"Healhty","enrollment":12},{"nctId":"NCT04469959","phase":"PHASE2","title":"Dopaminergic Dysfunction in Late-Life Depression","status":"ACTIVE_NOT_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2021-02-15","conditions":"Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant","enrollment":100},{"nctId":"NCT07349277","phase":"","title":"Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia","status":"RECRUITING","sponsor":"Ammar Jassim Abed","startDate":"2025-10-10","conditions":"Preeclampsia, Gestational Hypertension, Hypertensive Disorders of Pregnancy","enrollment":120},{"nctId":"NCT06618521","phase":"NA","title":"Effect of Pilates Exercise Versus Circuit Exercise Training on Gestational Hypertension","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-09-30","conditions":"Gestational Hypertension","enrollment":69},{"nctId":"NCT06587217","phase":"PHASE1, PHASE2","title":"Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Supplemental Open-Label Arm","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2024-10-29","conditions":"Parkinsonian Signs in Older Persons","enrollment":5},{"nctId":"NCT04520178","phase":"PHASE2, PHASE3","title":"Effects of 5HTP on the Injured Human Spinal Cord","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2020-07-01","conditions":"Spinal Cord Injuries","enrollment":30},{"nctId":"NCT04821830","phase":"PHASE4","title":"Vigor and the LDR in Parkinson Disease","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2020-02-12","conditions":"Parkinson Disease","enrollment":19},{"nctId":"NCT07044232","phase":"PHASE4","title":"NICardipine for Fast Achievement of Systolic BP Targets in ICH","status":"NOT_YET_RECRUITING","sponsor":"Aarhus University Hospital","startDate":"2025-10-01","conditions":"Intracerebral Haemorrhage","enrollment":88},{"nctId":"NCT06219915","phase":"PHASE1, PHASE2","title":"Neurobiological Drivers of Mobility Resilience: The Dopaminergic System - Placebo-Controlled Arm","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2024-03-15","conditions":"Parkinsonian Signs in Older Persons","enrollment":13},{"nctId":"NCT03735901","phase":"PHASE3","title":"Enhancement of Stroke Rehabilitation With Levodopa","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2019-06-14","conditions":"Acute Stroke, Stroke Rehabilitation","enrollment":610},{"nctId":"NCT04325503","phase":"PHASE1, PHASE2","title":"Neurobiological Drivers of Mobility Resilience: The Dopaminergic System","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2021-02-08","conditions":"Parkinsonian Signs in Older Persons","enrollment":14},{"nctId":"NCT06161220","phase":"PHASE1","title":"A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjects","status":"COMPLETED","sponsor":"Impax Laboratories, LLC","startDate":"2023-10-30","conditions":"Cardiac Repolarization in Healthy Subjects","enrollment":35},{"nctId":"NCT01323374","phase":"PHASE2","title":"Study To Assess The Clinical Benefit Of Droxidopa And Droxidopa/Carbidopa In Subjects With Fibromyalgia","status":"COMPLETED","sponsor":"Chelsea Therapeutics","startDate":"2009-01","conditions":"Fibromyalgia","enrollment":122},{"nctId":"NCT01883505","phase":"PHASE2","title":"A Phase 2a Study Followed to Evaluate the Safety, Tolerability and Levodopa Pharmacokinetics in Levodopa-treated Parkinson's Disease Patients Receiving ND0612","status":"COMPLETED","sponsor":"NeuroDerm Ltd.","startDate":"2014-01-06","conditions":"Parkinson's Disease","enrollment":30},{"nctId":"NCT04835233","phase":"PHASE4","title":"Management of Hypertension in the Early Postpartum: a Randomized Controlled Trial","status":"COMPLETED","sponsor":"Federal University of Paraíba","startDate":"2021-05-01","conditions":"Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia, Hypertension","enrollment":180},{"nctId":"NCT06180720","phase":"PHASE1","title":"Bioequivalence Study of Entacapone,Levodopa and Carbidopa Tablets in the Postprandial State in Healthy Chinese Subjects","status":"UNKNOWN","sponsor":"The Affiliated Hospital of Qingdao University","startDate":"2023-12-20","conditions":"Healthy","enrollment":36},{"nctId":"NCT05888896","phase":"NA","title":"Effect of Foot Reflexology on Preeclampsia","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-06-09","conditions":"Mild Pre-eclampsia","enrollment":60},{"nctId":"NCT01770145","phase":"PHASE4","title":"Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT)","status":"COMPLETED","sponsor":"MDD US Operations, LLC a subsidiary of Supernus Pharmaceuticals","startDate":"2012-12","conditions":"Parkinson's Disease, Motor Symptoms, Akinesia","enrollment":127},{"nctId":"NCT05976737","phase":"PHASE1","title":"Bioequivalence Study of Entacapone,Levodopa and Carbidopa Tablets in Healthy Chinese Subjects","status":"UNKNOWN","sponsor":"The Affiliated Hospital of Qingdao University","startDate":"2023-08-17","conditions":"Healthy","enrollment":68},{"nctId":"NCT03761030","phase":"PHASE4","title":"L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults","status":"TERMINATED","sponsor":"New York State Psychiatric Institute","startDate":"2019-01-09","conditions":"Major Depressive Disorder, Dysthymia, Depression","enrollment":51},{"nctId":"NCT04952194","phase":"PHASE4","title":"Clinical Study of Stalevo in the Treatment of Early Parkinson's Disease","status":"UNKNOWN","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2022-01-01","conditions":"Parkinson Disease","enrollment":180},{"nctId":"NCT04380142","phase":"PHASE3","title":"Study Comparing Continuous Subcutaneous Infusion Of ABBV-951 With Oral Carbidopa/Levodopa Tablets For Treatment Of Motor Fluctuations In Adult Participants With Advanced Parkinson's Disease","status":"COMPLETED","sponsor":"AbbVie","startDate":"2020-10-19","conditions":"Parkinson's Disease (PD)","enrollment":174},{"nctId":"NCT04000919","phase":"PHASE2, PHASE3","title":"Effects of 5HTP and LDOPA on CNS Excitability After SCI","status":"SUSPENDED","sponsor":"Jessica M D'Amico","startDate":"2019-06-19","conditions":"Spinal Cord Injuries","enrollment":30},{"nctId":"NCT03205956","phase":"PHASE1","title":"Measuring Parkinson's Disease Progression","status":"COMPLETED","sponsor":"Kevin J. Black, MD","startDate":"2017-10-19","conditions":"Parkinson's Disease","enrollment":31},{"nctId":"NCT05211609","phase":"NA","title":"Prevalence of High Plasmatic 3OMethyldopa Level in a Specific Population of Patients With a Symptomatology Compatible With AADC Deficiency","status":"UNKNOWN","sponsor":"University Hospital, Montpellier","startDate":"2022-05-20","conditions":"Aromatic L-Amino Acid Decarboxylase Deficiency","enrollment":388},{"nctId":"NCT04778176","phase":"PHASE2","title":"Assessing the Pharmacokinetics, Safety, Tolerability and Efficacy of Continuous Oral Levodopa Via the DopaFuse® Delivery System in Parkinson's Disease Patients","status":"COMPLETED","sponsor":"SynAgile Corporation","startDate":"2021-06-16","conditions":"Parkinson's Disease","enrollment":17},{"nctId":"NCT05250141","phase":"PHASE1","title":"Bioavailability of Levodopa 250 mg and Carbidopa 25 mg With Regards to Reference Product","status":"COMPLETED","sponsor":"Laboratorios Andromaco S.A.","startDate":"2022-02-14","conditions":"Bioequivalence","enrollment":44},{"nctId":"NCT02553265","phase":"PHASE2","title":"Carbidopa for the Treatment of Excessive Blood Pressure Variability","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2015-09","conditions":"Dysautonomia, Familial, Baroreflex Failure Syndrome","enrollment":22},{"nctId":"NCT00685919","phase":"PHASE2, PHASE3","title":"Peripheral Dopamine in Postural Tachycardia Syndrome","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2008-05","conditions":"Postural Tachycardia Syndrome, Orthostatic Intolerance","enrollment":32},{"nctId":"NCT01883804","phase":"NA","title":"Effect of Methyldopa on MHC Class II Antigen Presentation in Type 1 Diabetes","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2013-06","conditions":"Diabetes Mellitus, Type 1","enrollment":30},{"nctId":"NCT04625595","phase":"PHASE1","title":"Multiple Ascending Dose (MAD) Study of IMT-002 in HLA-DQ8-positive Type 1 Diabetes","status":"COMPLETED","sponsor":"Immunomolecular Therapeutics, Inc.","startDate":"2020-11-09","conditions":"Type1 Diabetes","enrollment":30},{"nctId":"NCT04764383","phase":"PHASE2","title":"Histaminergic Basis of Fatigue in Multiple Sclerosis","status":"WITHDRAWN","sponsor":"University of Miami","startDate":"2022-01-01","conditions":"Multiple Sclerosis","enrollment":""},{"nctId":"NCT03055936","phase":"PHASE1","title":"Dose-finding Pharmacokinetic Study in Healthy Males","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2017-02-21","conditions":"Healthy Volunteers","enrollment":56},{"nctId":"NCT00748059","phase":"PHASE1","title":"The Pathophysiology of Orthostatic Hypotension","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"1996-12","conditions":"Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency","enrollment":10},{"nctId":"NCT00914602","phase":"PHASE1, PHASE2","title":"An Exploratory Study of XP21279 (With Lodosyn®) and Sinemet® in Parkinson's Disease Subjects","status":"COMPLETED","sponsor":"XenoPort, Inc.","startDate":"2009-05","conditions":"Parkinson's Disease","enrollment":14},{"nctId":"NCT04467931","phase":"","title":"ACEI or ARB and COVID-19 Severity and Mortality in US Veterans","status":"COMPLETED","sponsor":"University of Utah","startDate":"2020-01-19","conditions":"Hypertension, COVID","enrollment":22213},{"nctId":"NCT02531490","phase":"PHASE4","title":"Early Vascular Adjustments During Hypertensive Pregnancy","status":"UNKNOWN","sponsor":"Maastricht University Medical Center","startDate":"2015-01-01","conditions":"Hypertension, Pregnancy-Induced, Pre-Eclampsia","enrollment":368},{"nctId":"NCT01683253","phase":"PHASE4","title":"Remission of ICD by Switching Dopamine Agonist to Levodopa/Carbidopa","status":"COMPLETED","sponsor":"Sandoz","startDate":"2012-11","conditions":"Impulse Control Disorder","enrollment":150},{"nctId":"NCT01171313","phase":"PHASE2","title":"A Efficacy, Safety and Pharmacokinetic Study of XP21279 and Sinemet® in Parkinson's Disease Subjects","status":"COMPLETED","sponsor":"XenoPort, Inc.","startDate":"2010-07","conditions":"Parkinson's Disease","enrollment":35},{"nctId":"NCT03266965","phase":"PHASE1","title":"Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach","status":"COMPLETED","sponsor":"University of Miami","startDate":"2018-03-23","conditions":"Multiple Sclerosis","enrollment":18},{"nctId":"NCT02799381","phase":"PHASE3","title":"A Study Comparing Efficacy of Levodopa-Carbidopa Intestinal Gel/Carbidopa-Levodopa Enteral Suspension and Optimized Medical Treatment on Dyskinesia in Subjects With Advanced Parkinson's Disease (DYSCOVER)","status":"COMPLETED","sponsor":"AbbVie","startDate":"2017-02-09","conditions":"Parkinson's Disease (PD)","enrollment":63},{"nctId":"NCT03541356","phase":"PHASE2","title":"Therapeutic Potential for Intranasal Levodopa in Parkinson's Disease -Off Reversal","status":"COMPLETED","sponsor":"Impel Pharmaceuticals","startDate":"2018-05-08","conditions":"Parkinson's Disease","enrollment":32},{"nctId":"NCT03396484","phase":"PHASE2","title":"Methyldopa for Reduction of DQ8 Antigen Presentation in At-Risk Subjects for Type 1 Diabetes","status":"WITHDRAWN","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2020-09","conditions":"Type1 Diabetes Mellitus","enrollment":""},{"nctId":"NCT04216706","phase":"","title":"Early Vascular Adjustments to Prevent Preeclampsia","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2014-11-01","conditions":"Preeclampsia, Small for Gestational Age at Delivery, HELLP Syndrome","enrollment":314},{"nctId":"NCT03115827","phase":"PHASE4","title":"Norepinephrine-targeted Therapy for Action Control in Parkinson Disease","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2017-04-18","conditions":"Parkinson Disease","enrollment":15},{"nctId":"NCT04082715","phase":"PHASE2","title":"Transition From Acute to Chronic Back Pain : Effect of L-dopa,Gender,and Associated Brain Plasticity","status":"WITHDRAWN","sponsor":"Second Affiliated Hospital of Wenzhou Medical University","startDate":"2019-10","conditions":"Chronic Back Pain","enrollment":""},{"nctId":"NCT01399905","phase":"PHASE2","title":"High and Low Dose Carbidopa Treatment of Parkinson's Disease","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2009-03","conditions":"Parkinson's Disease","enrollment":14},{"nctId":"NCT01911494","phase":"NA","title":"Community Level Interventions for Pre-eclampsia","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2013-09","conditions":"Pre-eclampsia, Hypertension, Pregnancy Induced","enrollment":87500},{"nctId":"NCT01912677","phase":"PHASE4","title":"Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2015-04","conditions":"Hypertension in Pregnancy, Preeclampsia","enrollment":894},{"nctId":"NCT00845000","phase":"PHASE1","title":"Acute Effects of Preladenant (SCH 420814) on Dyskinesia and Parkinsonism in Levodopa Treated Participants (P05550)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2009-04-21","conditions":"Parkinson Disease","enrollment":12},{"nctId":"NCT03576638","phase":"PHASE2","title":"Study to Assess Pharmacokinetics of Accordion Pill Carbidopa-Levodopa Compared to Immediate Release Carbidopa-Levodopa in Parkinson's Disease Patients","status":"UNKNOWN","sponsor":"Intec Pharma Ltd.","startDate":"2018-07","conditions":"Parkinson Disease","enrollment":12},{"nctId":"NCT01437293","phase":"PHASE1","title":"Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE)","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2010-08","conditions":"Cocaine Abuse","enrollment":15},{"nctId":"NCT00329511","phase":"NA","title":"A Comparison of Compliance Between Clonidine Patch and Methyldopa for the Treatment of Chronic Hypertension in Pregnancy","status":"WITHDRAWN","sponsor":"Afshan B. Hameed, M.D.","startDate":"2004-09","conditions":"Hypertension","enrollment":""},{"nctId":"NCT03210025","phase":"PHASE1","title":"Clinical Bioequivalence Study on Two Methyldopa Tablet 250mg Formulations","status":"COMPLETED","sponsor":"Bright Future Pharmaceuticals Factory O/B Bright Future Pharmaceutical Laboratories Limited","startDate":"2017-09-20","conditions":"Healthy","enrollment":17},{"nctId":"NCT00223717","phase":"PHASE1","title":"Treatment of Supine Hypertension in Autonomic Failure","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2001-01","conditions":"Hypertension","enrollment":152},{"nctId":"NCT03140956","phase":"PHASE1","title":"Pharmacokinetic of Levodopa Study in Healthy Males","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2017-04-19","conditions":"Parkinson Disease","enrollment":20},{"nctId":"NCT01617135","phase":"PHASE2","title":"Safety, Pharmacokinetics and Efficacy Study of CVT-301 Inpatients With Parkinson's Disease and \"Off\" Episodes","status":"COMPLETED","sponsor":"Acorda Therapeutics","startDate":"2012-05","conditions":"Idiopathic Parkinson's Disease","enrollment":25},{"nctId":"NCT00194974","phase":"PHASE1, PHASE2","title":"Treatment Targets for Chronic Hypertension in Pregnancy","status":"WITHDRAWN","sponsor":"Weill Medical College of Cornell University","startDate":"2004-07","conditions":"Pregnancy Toxemia, Hypertension, Proteinuria","enrollment":""},{"nctId":"NCT00580619","phase":"PHASE1","title":"Autonomic Nervous System and Chronic Fatigue Syndrome","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2007-04","conditions":"Chronic Fatigue Syndrome, Orthostatic Intolerance, Postural Tachycardia Syndrome","enrollment":170},{"nctId":"NCT00223691","phase":"PHASE1","title":"Treatment of Orthostatic Hypotension in Autonomic Failure","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2002-03","conditions":"Autonomic Failure, Orthostatic Hypotension","enrollment":389},{"nctId":"NCT00829439","phase":"PHASE1","title":"Study on Tolerability of Levodopa/Carbidopa in Children With Angelman Syndrome","status":"COMPLETED","sponsor":"Boston Children's Hospital","startDate":"2009-01","conditions":"Angelman Syndrome","enrollment":16},{"nctId":"NCT01500590","phase":"PHASE4","title":"Effect of Renin-angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria","status":"UNKNOWN","sponsor":"Hospital Authority, Hong Kong","startDate":"2011-11","conditions":"Diabetes, Hypertensive Disease","enrollment":1400},{"nctId":"NCT00141518","phase":"PHASE4","title":"Long-term Study of Duodopa (Levodopa/Carbidopa) in Advanced Parkinson's: Health Outcomes & Net Economic Impact","status":"COMPLETED","sponsor":"AbbVie (prior sponsor, Abbott)","startDate":"2006-03","conditions":"Advanced Idiopathic Parkinson's Disease","enrollment":77},{"nctId":"NCT02633839","phase":"PHASE1","title":"A Study of the Safety and Levodopa Pharmacokinetics Following Single Dose Administration of CVT 301 (Levodopa Inhalation Powder) in Smoking and Non-Smoking Adults","status":"COMPLETED","sponsor":"Acorda Therapeutics","startDate":"2015-12","conditions":"Smoking","enrollment":60},{"nctId":"NCT02633007","phase":"PHASE1","title":"A Study of the Safety and Pharmacokinetics of Levodopa Following Administration of CVT 301 (Levodopa Inhalation Powder) in Adults With Asthma","status":"COMPLETED","sponsor":"Acorda Therapeutics","startDate":"2015-12","conditions":"Asthma","enrollment":25},{"nctId":"NCT01479127","phase":"PHASE2","title":"Study of Safety, Tolerability, Pharmacokinetics, and Efficacy of ABT-SLV187 in Subjects With Advanced Parkinson's Disease","status":"COMPLETED","sponsor":"AbbVie (prior sponsor, Abbott)","startDate":"2011-10","conditions":"Advanced Parkinson's Disease","enrollment":8},{"nctId":"NCT01212484","phase":"PHASE3","title":"Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2009-12","conditions":"Familial Dysautonomia","enrollment":12},{"nctId":"NCT01636037","phase":"PHASE2","title":"Antipsychotic Augmentation With L-Dopa","status":"COMPLETED","sponsor":"Centre for Addiction and Mental Health","startDate":"2012-09","conditions":"Schizophrenia","enrollment":13},{"nctId":"NCT02554734","phase":"PHASE1","title":"Pharmacokinetic Study in Healthy Volunteers","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2015-08","conditions":"Parkinson's Disease","enrollment":15},{"nctId":"NCT00218075","phase":"PHASE2","title":"Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2000-03","conditions":"Cocaine Abuse, Cocaine-Related Disorders","enrollment":200},{"nctId":"NCT01533077","phase":"PHASE1","title":"Pharmacokinetic Interaction Between BIA 9-1067 and Standard-release Levodopa/Carbidopa","status":"COMPLETED","sponsor":"Bial - Portela C S.A.","startDate":"2009-03","conditions":"Parkinson Disease","enrollment":18},{"nctId":"NCT01470859","phase":"NA","title":"The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease","status":"COMPLETED","sponsor":"Huashan Hospital","startDate":"2011-12","conditions":"Idiopathic Parkinson's Disease","enrollment":30},{"nctId":"NCT01227655","phase":"PHASE3","title":"Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients.","status":"COMPLETED","sponsor":"Bial - Portela C S.A.","startDate":"2011-03","conditions":"Parkinson's Disease","enrollment":427},{"nctId":"NCT01568073","phase":"PHASE3","title":"Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients With \"Wearing-off\" Phenomenon","status":"COMPLETED","sponsor":"Bial - Portela C S.A.","startDate":"2011-03","conditions":"Parkinson's Disease","enrollment":600},{"nctId":"NCT02486432","phase":"PHASE1","title":"A Single Period Investigation to Assess the Tolerability of Healthy Subjects to Oral Sinemet® (Levodopa/Carbidopa)","status":"COMPLETED","sponsor":"NeuroDerm Ltd.","startDate":"2015-04","conditions":"Parkinson's Disease","enrollment":6},{"nctId":"NCT02312232","phase":"PHASE1","title":"Pharmacokinetic Study in Healthy Males","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2014-11","conditions":"Parkinson's Disease","enrollment":20},{"nctId":"NCT00547911","phase":"PHASE1, PHASE2","title":"Augmenting Effects of L-DOPS With Carbidopa and Entacapone","status":"TERMINATED","sponsor":"National Institute of Neurological Disorders and Stroke (NINDS)","startDate":"2007-10","conditions":"Parkinson Disease, Multiple System Atrophy, Autonomic Nervous System Diseases","enrollment":14},{"nctId":"NCT01766258","phase":"PHASE2","title":"Efficacy and Safety Proof of Concept Study in Patients With Parkinson's Disease and End-of-dose Motor Fluctuations","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2011-05","conditions":"Parkinson's Disease","enrollment":117},{"nctId":"NCT01218425","phase":"NA","title":"Dopaminergic Modulation of Cognition and Psychomotor Function","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2010-11","conditions":"Dopamine Activity, Episodic Memory Consolidation, Response Preparation","enrollment":20},{"nctId":"NCT01674127","phase":"PHASE2","title":"Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia","status":"COMPLETED","sponsor":"Isfahan University of Medical Sciences","startDate":"2011-08","conditions":"Pregnant Women With Mild Preeclampsia","enrollment":50},{"nctId":"NCT01229332","phase":"PHASE1, PHASE2","title":"A Safety, Tolerability and Pharmacokinetic Study of ND0611 on the Top of Different Oral Dosage Forms of Levodopa/Carbidopa in Parkinson's Disease Patients","status":"COMPLETED","sponsor":"NeuroDerm Ltd.","startDate":"2011-01","conditions":"Parkinson's Disease","enrollment":24},{"nctId":"NCT01296464","phase":"PHASE2","title":"Comparing Different Levodopa/Carbidopa/Entacapone Treatment Regimens","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2011-02","conditions":"Parkinson's Disease","enrollment":27},{"nctId":"NCT01361425","phase":"PHASE4","title":"Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape)","status":"UNKNOWN","sponsor":"Professor Fernando Figueira Integral Medicine Institute","startDate":"2011-05","conditions":"Preeclampsia","enrollment":200},{"nctId":"NCT01070628","phase":"PHASE1","title":"Levodopa Concentration Profile With Stalevo 75/125 mg","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2009-12","conditions":"Parkinson's Disease","enrollment":20},{"nctId":"NCT00117546","phase":"PHASE4","title":"Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia","status":"UNKNOWN","sponsor":"Radboud University Medical Center","startDate":"2005-09","conditions":"Preeclampsia","enrollment":35},{"nctId":"NCT00460954","phase":"","title":"A Multiple-Dose Study of Sinemet® CR (Carbidopa/Levodopa) in Healthy Subjects","status":"COMPLETED","sponsor":"Bristol-Myers Squibb","startDate":"2007-06","conditions":"Parkinson's Disease","enrollment":20},{"nctId":"NCT00562198","phase":"PHASE2","title":"PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding","status":"TERMINATED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2008-01","conditions":"Parkinson´s Disease","enrollment":16},{"nctId":"NCT00693862","phase":"PHASE1","title":"Pharmacokinetic Study With Repeated Doses of Stalevo","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2006-12","conditions":"Pharmacokinetics","enrollment":19},{"nctId":"NCT00684489","phase":"NA","title":"Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2003-09","conditions":"Hypertension","enrollment":52},{"nctId":"NCT00174239","phase":"PHASE4","title":"Study Of Cabaser and Sinemet CR For The Treatment Of Nighttime Symptoms Associated With Parkinson's Disease.","status":"TERMINATED","sponsor":"Pfizer","startDate":"2004-07","conditions":"Parkinson Disease","enrollment":220}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Aldomet"],"phase":"marketed","status":"active","brandName":"alpha methyldopa","genericName":"alpha methyldopa","companyName":"Radboud University Medical Center","companyId":"radboud-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alpha methyldopa is a prodrug that is converted to alpha-methylnorepinephrine, which acts as a central-acting alpha-2 adrenergic agonist to reduce sympathetic outflow and lower blood pressure. Used for Hypertension, Hypertension in pregnancy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}