{"id":"alpha-lipoic-acid-la","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL33864","moleculeType":"Small molecule","molecularWeight":"206.33"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alpha-lipoic acid (ALA) is a naturally occurring compound that functions as a coenzyme in mitochondrial dehydrogenase complexes, facilitating energy production. It also acts as a free radical scavenger, reducing oxidative stress and inflammation. Additionally, ALA can regenerate other antioxidants like vitamins C and E, enhancing overall antioxidant defense.","oneSentence":"Alpha-lipoic acid acts as a mitochondrial cofactor and antioxidant that reduces oxidative stress and improves cellular energy metabolism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:21:16.863Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diabetic peripheral neuropathy"},{"name":"Diabetic complications"},{"name":"Oxidative stress-related conditions"}]},"trialDetails":[{"nctId":"NCT03491969","phase":"PHASE4","title":"Clinical Study of Lipoic Acid on Ischemic Heart Failure","status":"COMPLETED","sponsor":"Shanghai Zhongshan Hospital","startDate":"2019-01-01","conditions":"Ischemic Heart Failure","enrollment":300},{"nctId":"NCT04436419","phase":"NA","title":"Immunometabolic Effects of Non-drug Strategies in the Clinical Management of Obesity: Translational Study","status":"COMPLETED","sponsor":"Fauqué","startDate":"2018-07-02","conditions":"Obesity, Obesity, Abdominal, Obesity, Visceral","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":230,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Alpha-Lipoic Acid(α-LA)","genericName":"Alpha-Lipoic Acid(α-LA)","companyName":"Shanghai Zhongshan Hospital","companyId":"shanghai-zhongshan-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alpha-lipoic acid acts as a mitochondrial cofactor and antioxidant that reduces oxidative stress and improves cellular energy metabolism. Used for Diabetic peripheral neuropathy, Diabetic complications, Oxidative stress-related conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}