{"id":"alpha-blocker-or-5-ari-withdrawal","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"5-10%","effect":"Orthostatic hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Alpha-blockers, such as tamsulosin, work by selectively blocking alpha-1 adrenergic receptors in the smooth muscle of the prostate and bladder neck, leading to relaxation of these muscles and decreased resistance to urine flow. This results in improved urinary symptoms in men with benign prostatic hyperplasia (BPH).","oneSentence":"Alpha-blockers block alpha-1 adrenergic receptors, causing smooth muscle relaxation and vasodilation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:44:27.160Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Benign prostatic hyperplasia (BPH)"},{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT05023824","phase":"PHASE3","title":"Efficacy of α-blocker or 5-ARI Withdrawal to Continued Combination Therapy on the Maintenance of LUTS in Men With BPH","status":"UNKNOWN","sponsor":"Gangnam Severance Hospital","startDate":"2020-12-08","conditions":"Prostatic Hyperplasia, Prostate Hyperplasia, Prostatic Hypertrophy","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":64750,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["alpha-blocker withdrawal","5-ARI withdrawal"],"phase":"phase_3","status":"active","brandName":"alpha-blocker or 5-ARI withdrawal","genericName":"alpha-blocker or 5-ARI withdrawal","companyName":"Gangnam Severance Hospital","companyId":"gangnam-severance-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alpha-blockers block alpha-1 adrenergic receptors, causing smooth muscle relaxation and vasodilation. Used for Benign prostatic hyperplasia (BPH), Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}