{"id":"alpha-blocker-and-nsaid","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Orthostatic hypotension"},{"rate":null,"effect":"Dyspepsia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alpha-blockers relax smooth muscle in the prostate and bladder neck, improving urinary flow and reducing lower urinary tract symptoms. NSAIDs inhibit prostaglandin synthesis by blocking COX-1 and COX-2 enzymes, providing anti-inflammatory and analgesic effects. Together, they address both obstructive and inflammatory components of urological conditions.","oneSentence":"This combination blocks alpha-adrenergic receptors to relax smooth muscle in the urinary tract while inhibiting cyclooxygenase enzymes to reduce inflammation and pain.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:42:21.275Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Lower urinary tract symptoms associated with benign prostatic hyperplasia"},{"name":"Dysuria and urinary discomfort"}]},"trialDetails":[{"nctId":"NCT00687388","phase":"PHASE4","title":"The Clinical Efficacy of Non-steroidal Anti-inflammation Drugs in Patients With Benign Prostatic Hyperplasia","status":"WITHDRAWN","sponsor":"Samsung Medical Center","startDate":"2008-05","conditions":"Benign Prostatic Hyperplasia","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["tamsulosin and celecoxib","alfuzosin and celecoxib","doxazosin and celecoxib","terazosin and celecoxib"],"phase":"marketed","status":"active","brandName":"alpha-blocker and NSAID","genericName":"alpha-blocker and NSAID","companyName":"Samsung Medical Center","companyId":"samsung-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination blocks alpha-adrenergic receptors to relax smooth muscle in the urinary tract while inhibiting cyclooxygenase enzymes to reduce inflammation and pain. Used for Lower urinary tract symptoms associated with benign prostatic hyperplasia, Dysuria and urinary discomfort.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}