{"id":"almotriptan-or-pseudoephedrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Chest pain or tightness"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Paresthesia"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Palpitations"}]},"_chembl":{"chemblId":"CHEMBL1505","moleculeType":"Small molecule","molecularWeight":"335.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Almotriptan works by binding to serotonin 5-HT1B and 5-HT1D receptors on cranial blood vessels and nerve terminals, causing vasoconstriction and reducing neurogenic inflammation associated with migraine. Pseudoephedrine acts as an alpha-adrenergic agonist to reduce nasal congestion. The combination targets both migraine symptoms and associated sinus congestion.","oneSentence":"This is a combination product containing almotriptan (a selective 5-HT1B/1D receptor agonist for migraine) and pseudoephedrine (a sympathomimetic nasal decongestant).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:11.794Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine with or without aura, with associated nasal congestion"}]},"trialDetails":[{"nctId":"NCT00208065","phase":"PHASE4","title":"Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers","status":"COMPLETED","sponsor":"Clinvest","startDate":"2004-05","conditions":"Migraine, Sinusitis","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"almotriptan or pseudoephedrine","genericName":"almotriptan or pseudoephedrine","companyName":"Clinvest","companyId":"clinvest","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination product containing almotriptan (a selective 5-HT1B/1D receptor agonist for migraine) and pseudoephedrine (a sympathomimetic nasal decongestant). Used for Acute migraine with or without aura, with associated nasal congestion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}