{"id":"almecillin","rwe":[],"tags":[{"label":"almecillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"penicillin o","offLabel":[],"synonyms":["allomercaptomethylpenicillin","allylmercaptomethylpenicillin","allylmercaptomethylpenicillinic acid","allylthiomethylpenicillin","almecillin","Penicillin O"],"timeline":[],"brandName":"Penicillin O","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"almecillin","explanation":"Imagine your body's cells are like houses, and the bacteria are like construction workers trying to build new houses. Almecillin is like a tool that prevents the construction workers from building the houses, effectively stopping the bacteria from growing and multiplying.","oneSentence":"Almecillin works by inhibiting bacterial cell wall synthesis.","technicalDetail":"Almecillin exerts its antibacterial effects by binding to and inhibiting the transpeptidase enzyme, which is essential for bacterial cell wall synthesis."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Almecillin","title":"Almecillin","extract":"Almecillin (INN), also known as penicillin O, is a penicillin that is similar in antibiotic action to penicillin G. It is obtained by isolation from Penicillium chrysogenum."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3422","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ALMECILLIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALMECILLIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Almecillin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:38:09.660389","biosimilars":[],"competitors":[],"genericName":"almecillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT04041791","phase":"PHASE3","title":"A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2019-08-19","conditions":["Pneumonia"],"enrollment":4392,"completionDate":"2024-04-05"},{"nctId":"NCT06414694","phase":"PHASE4","title":"Inpatient Penicillin Delabeling for Low-Risk Patients","status":"ENROLLING_BY_INVITATION","sponsor":"University of Tennessee","startDate":"2023-09-01","conditions":["Penicillin","Drug Allergy"],"enrollment":25,"completionDate":"2025-09-30"},{"nctId":"NCT06058286","phase":"NA","title":"MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in Indonesia","status":"UNKNOWN","sponsor":"Yanri Wijayanti Subronto, MD, PhD,","startDate":"2023-10-01","conditions":["Hiv","Syphilis","Hepatitis B"],"enrollment":2000,"completionDate":"2024-12-31"},{"nctId":"NCT02353117","phase":"NA","title":"Preventing Congenital Syphilis","status":"COMPLETED","sponsor":"Tulane University School of Public Health and Tropical Medicine","startDate":"2016-01-11","conditions":["Congenital Syphilis"],"enrollment":60386,"completionDate":"2018-02-28"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002699","UNII":"6246WH0S1O","CHEBI":"CHEBI:51207","INN_ID":"1575","UMLSCUI":"C0801851","ChEMBL_ID":"CHEMBL2105909","PUBCHEM_CID":"71365","SNOMEDCT_US":"117147001"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Infectious Disease"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Almecillin, also known as Penicillin O, is a small molecule antibiotic in the almecillin class. Unfortunately, there is limited information available on this medication. It is not clear what specific target it binds to or what its approved indications are. Almecillin's commercial status and safety considerations are also unknown. Further research is needed to fully understand this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}