{"id":"allylestrenol","rwe":[{"pmid":"41568769","year":"2026","title":"Allylestrenol Prevents Misoprostol-Induced Abortion in Mice via Progesterone Receptor-Dependent Anti-Inflammatory and Anti-Apoptotic Pathways.","finding":"","journal":"Biology of reproduction","studyType":"Clinical Study"},{"pmid":"41477181","year":"2025","title":"Preliminary Developmental Safety Assessment of Allylestrenol in Pregnant SD Rats: Evaluation of F0 and Early F1 Generational Endpoints.","finding":"","journal":"Drug design, development and therapy","studyType":"Clinical Study"},{"pmid":"41061300","year":"2025","title":"Applicability domain-expansion studies for machine learning models reveal new inhibitors of CYP2B6.","finding":"","journal":"Drug metabolism and disposition: the biological fate of chemicals","studyType":"Clinical Study"},{"pmid":"40385036","year":"2025","title":"Efficacy of allylestrenol combined with ritodrine in treating preterm labour with preeclampsia and associated risk factors for pregnancy outcomes.","finding":"","journal":"American journal of translational research","studyType":"Clinical Study"},{"pmid":"39822553","year":"2024","title":"Effects of allylestrenol on hormone levels and delivery outcomes in threatened abortion.","finding":"","journal":"American journal of translational research","studyType":"Clinical Study"}],"tags":[{"label":"allylestrenol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G03DC01","category":"atc"},{"label":"Active","category":"status"},{"label":"Hormones","category":"pharmacology"},{"label":"Progestins","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"gestanin","offLabel":[],"synonyms":["allylestrenol","gestanin","gestanol","gestanon","orageston"],"timeline":[],"brandName":"Gestanin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"allylestrenol","explanation":"In simple terms, Gestanin helps to maintain a healthy balance of hormones in the body, particularly progesterone, which is essential for pregnancy and menstrual cycles. By doing so, it can help to regulate the menstrual cycle and support pregnancy. This is achieved by binding to progesterone receptors in the body, triggering a series of downstream effects that help to maintain a healthy hormonal balance.","oneSentence":"Gestanin works by mimicking the effects of progesterone in the body.","technicalDetail":"Gestanin exerts its effects by binding to progesterone receptors, specifically the PR-B and PR-A isoforms, which triggers a cascade of signaling events that ultimately lead to the regulation of gene expression and the maintenance of a healthy hormonal balance."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Allylestrenol","title":"Allylestrenol","extract":"Allylestrenol, sold under the brand names Gestanin and Turinal among others, is a progestin medication which is used to treat recurrent and threatened miscarriage and to prevent premature labor in pregnant women. However, except in the case of proven progesterone deficiency, its use for such purposes is no longer recommended. A Cochrane review in 2025 found that it had little to no effect in subsequent pregnancy outcomes for women with unexplained, recurrent miscarriage. It is also used in Japan to treat benign prostatic hyperplasia (BPH) in men. The medication is used alone and is not formulated in combination with an estrogen. It is taken by mouth.","wiki_history":"==History==\nAllylestrenol was patented in 1958 and has been marketed for medical use since 1961. It was developed by Organon Laboratories.","wiki_society_and_culture":"==Society and culture==\n\n===Generic names===\nAllylestrenol is the generic name of the drug and its , , and , while allylestrénol is its  and allilestrenolo is its . The  was originally allyloestrenol, but it was eventually changed. However, although it has been widely marketed in the past, the availability of allylestrenol is relatively limited today. It appears to still be available in Bangladesh, the Czech Republic, Egypt, Hong Kong, India, Indonesia, Japan, Lithuania, Malaysia, the Philippines, Russia, Singapore, and Taiwan. Previously, allylestrenol has also been available in Australia, Austria, Belgium, Brazil, Germany, Greece, Hungary, Italy, Luxembourg, Mexico, Poland, South Africa, Spain, Sweden, Switzerland, Turkey, Ukraine, the United Kingdom, and Yugoslavia (now Serbia and Montenegro). However, it seems to have been discontinued in these countries. It does not seem to have been marketed in the United States or Canada."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/125","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALLYLESTRENOL","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Allylestrenol","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T08:38:05.741281","biosimilars":[],"competitors":[{"drugName":"norethisterone","drugSlug":"norethisterone","fdaApproval":"1962-05-21","relationship":"same-class"},{"drugName":"etynodiol","drugSlug":"etynodiol","fdaApproval":"1966-03-23","relationship":"same-class"}],"genericName":"allylestrenol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"norethisterone","brandName":"norethisterone","genericName":"norethisterone","approvalYear":"1962","relationship":"same-class"},{"drugId":"etynodiol","brandName":"etynodiol","genericName":"etynodiol","approvalYear":"1966","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000167406","NDDF":"003923","UNII":"I47VB5DZ8O","CHEBI":"CHEBI:31189","INN_ID":"953","RXNORM":"525","UMLSCUI":"C0002158","ChEMBL_ID":"CHEMBL2105618","KEGG_DRUG":"D01374","DRUGBANK_ID":"DB01431","PUBCHEM_CID":"235905","SNOMEDCT_US":"325584009","MESH_DESCRIPTOR_UI":"D000500"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03DC01","allCodes":["G03DC01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 22","pmid":"41568769","title":"Allylestrenol Prevents Misoprostol-Induced Abortion in Mice via Progesterone Receptor-Dependent Anti-Inflammatory and Anti-Apoptotic Pathways.","journal":"Biology of reproduction"},{"date":"2025","pmid":"41477181","title":"Preliminary Developmental Safety Assessment of Allylestrenol in Pregnant SD Rats: Evaluation of F0 and Early F1 Generational Endpoints.","journal":"Drug design, development and therapy"},{"date":"2025 Oct","pmid":"41061300","title":"Applicability domain-expansion studies for machine learning models reveal new inhibitors of CYP2B6.","journal":"Drug metabolism and disposition: the biological fate of chemicals"},{"date":"2025","pmid":"40385036","title":"Efficacy of allylestrenol combined with ritodrine in treating preterm labour with preeclampsia and associated risk factors for pregnancy outcomes.","journal":"American journal of translational research"},{"date":"2024","pmid":"39822553","title":"Effects of allylestrenol on hormone levels and delivery outcomes in threatened abortion.","journal":"American journal of translational research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Gestanin (allylestrenol) is a small molecule drug in the allylestrenol class, originally developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are unknown, but it is used to treat certain conditions. Gestanin's commercial status, including its patent status and generic availability, is also unknown. As a result, its safety profile, including its half-life and bioavailability, is not well-documented. Further research is needed to fully understand Gestanin's properties and uses.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}