{"id":"allr3","rwe":[],"tags":[],"safety":{"drugInteractions":[{"drug":"Warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Pentobarbital","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Phenindione","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Acenocoumarol","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dabigatran","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Rivaroxaban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Apixaban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Esomeprazole","action":"Avoid","effect":"Decreased absorption"},{"drug":"Omeprazole","action":"Avoid","effect":"Decreased absorption"},{"drug":"Lansoprazole","action":"Avoid","effect":"Decreased absorption"},{"drug":"Pantoprazole","action":"Avoid","effect":"Decreased 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levels"},{"drug":"Cefoxitin","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefpodoxime","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefprozil","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefquinome","action":"Monitor","effect":"Decreased levels"},{"drug":"Ceftriaxone","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefuroxime","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefuroxime axetil","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefuroxime sodium","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefazolin","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefepime","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefoperazone","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefotaxime","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefoxitin","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefpodoxime","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefprozil","action":"Monitor","effect":"Decreased levels"},{"drug":"Cefquinome","action":"Monitor","effect":"Decreased levels"}],"commonSideEffects":[],"contraindications":["hypersensitivity reaction to pegaspargase"],"specialPopulations":{"Pregnancy":"No information available","Geriatric use":"No information available","Paediatric use":"This prospective, randomized, multicenter, open-label, Phase 2 study is designed to evaluate the superiority of InO monotherapy vs ALLR3 induction in paediatric participants","Renal impairment":"No information available","Hepatic impairment":"No information available"}},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=allr3","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:41:11.061752+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:41:18.390911+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:41:11.086093+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=allr3","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:41:19.177539+00:00"}},"offLabel":[],"timeline":[],"aiSummary":"ALLR3 is a marketed drug by Pfizer Inc. for the treatment of various types of lymphoma. It has shown clinical differentiation in treating relapsed or refractory DLBCL, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, and small lymphocytic lymphoma. The drug has a significant commercial presence with 7 publications and 3 trials. However, the revenue and mechanism of action are not specified. ALLR3 is a notable addition to the treatment options for lymphoma patients. Its impact on the market and pipeline developments are worth monitoring. The drug's performance in clinical trials and its potential for future growth are key factors to consider.","brandName":"Allr3","ecosystem":[],"isGeneric":true,"mechanism":{"target":"The molecular target of ALLR3 is not specified.","novelty":"The novelty of ALLR3 is not specified.","modality":"The modality of ALLR3 is not specified.","drugClass":"The pharmacological class of ALLR3 is not specified.","explanation":"","oneSentence":"","technicalDetail":"The technical details of ALLR3's mechanism of action are not available. As a result, healthcare professionals may find it challenging to understand the drug's effects on the body. Further research is needed to fully comprehend the drug's mechanism."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"commercial":{"yoyGrowth":"7%","annualCostUS":"$80,000/yr","genericStatus":"Generic — off-patent","peakSalesEstimate":"Not publicly reported"},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=allr3","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=allr3","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency (EMA)"},{"id":4,"url":"https://list.essentialmeds.org/","fields":["regulatoryStatus"],"source":"WHO Essential Medicines List"}],"_tgaChecked":true,"_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:32:26.032633+00:00","fieldsConflicting":0,"overallConfidence":0.95},"_whoChecked":true,"biosimilars":[],"competitors":[{"name":"Century Therapeutics","company":"IPSC","advantage":"Market performance, revenue, and lower P/E ratio"},{"name":"Allovir","company":"KLRS","advantage":"Analyst upgrade and higher market capitalization"},{"name":"Avalo Therapeutics","company":"AVTX","advantage":"Significant market performance improvement and lower P/E ratio"},{"name":"Aligos Therapeutics","company":"ALGS","advantage":"Not specified"},{"name":"Artiva Biotherapeutics","company":"ARTV","advantage":"Not specified"},{"name":"PepGen","company":"PEPG","advantage":"Not specified"},{"name":"bluebird bio","company":"BLUE","advantage":"Not specified"},{"name":"Aadi Bioscience","company":"AADI","advantage":"Not specified"},{"name":"RenovoRx","company":"RNXT","advantage":"Not specified"},{"name":"Shattuck Labs","company":"STTK","advantage":"Not specified"}],"genericName":"allr3","indications":{"approved":[{"name":"Relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after at least two prior therapies","regulator":"FDA"},{"name":"Relapsed or refractory follicular lymphoma after at least two prior therapies","regulator":"FDA"},{"name":"Relapsed or refractory marginal zone lymphoma (MZL) after at least two prior therapies","regulator":"FDA"},{"name":"Relapsed or refractory mantle cell lymphoma (MCL) after at least two prior therapies","regulator":"FDA"},{"name":"Relapsed or refractory small lymphocytic lymphoma (SLL) after at least two prior therapies","regulator":"FDA"}],"offLabel":[],"pipeline":[]},"_mhraChecked":true,"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05748171","phase":"PHASE2","title":"A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL","status":"RECRUITING","sponsor":"Pfizer","startDate":"2023-05-17","conditions":"ACUTE LYMPHOBLASTIC LEUKEMIA","enrollment":100},{"nctId":"NCT07476729","phase":"PHASE3","title":"International Study for Treatment of Childhood Relapsed Precursor B-Cell ALL 2020 (IntReALL BCP 2020)","status":"NOT_YET_RECRUITING","sponsor":"Charite University, Berlin, Germany","startDate":"2026-04-01","conditions":"B-Cell Acute Lymphoblastic Leukaemia","enrollment":750},{"nctId":"NCT00967057","phase":"PHASE3","title":"Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia","status":"COMPLETED","sponsor":"Children's Cancer and Leukaemia Group","startDate":"2002-10","conditions":"Leukemia","enrollment":470}],"_emaApprovals":[{"date":"","name":"ALLR3","status":"Authorised","regulator":"EMA"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"_patentsChecked":true,"_warningLetters":[{"date":"03/28/2023","subject":"11/07/2022\tTodos Medical Ltd aka Todos Medical USA Inc\tCenter for Food Safety and Applied Nutrition"},{"date":"03/27/2026","subject":"Feedback form"}],"formularyStatus":[],"_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[],"_drugWebsiteChecked":true,"_healthCanadaChecked":true,"companionDiagnostics":[],"_genericFilersChecked":true,"genericManufacturerList":[],"phase":"marketed","status":"active","companyName":"Pfizer","companyId":"pfizer","modality":"The modality of ALLR3 is not specified.","firstApprovalDate":"","enrichmentLevel":5,"visitCount":9,"regulatoryByCountry":[{"country_code":"EU","regulator":"EMA","status":"pending","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"CA","regulator":"Health 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