{"id":"allopurinol-sustained-release-capsules","safety":{"commonSideEffects":[{"rate":"2-3","effect":"Rash"},{"rate":"1-3","effect":"Gastrointestinal upset (nausea, diarrhea)"},{"rate":"1-2","effect":"Elevated liver enzymes"},{"rate":"0.1-0.4","effect":"Hypersensitivity syndrome"},{"rate":"5-10","effect":"Gout flare (initial treatment)"}]},"_chembl":{"chemblId":"CHEMBL1467","moleculeType":"Small molecule","molecularWeight":"136.11"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Allopurinol is a purine analog that competitively inhibits xanthine oxidase, a key enzyme in the final steps of purine metabolism. By blocking this enzyme, it decreases the production of uric acid from its precursors. The sustained-release formulation provides prolonged drug exposure, allowing for once-daily dosing and more stable uric acid suppression compared to immediate-release formulations.","oneSentence":"Allopurinol inhibits xanthine oxidase, the enzyme responsible for converting hypoxanthine and xanthine to uric acid, thereby reducing serum and urinary uric acid levels.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:21:03.669Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gout prophylaxis and treatment"},{"name":"Hyperuricemia"},{"name":"Uric acid nephropathy prevention"},{"name":"Tumor lysis syndrome prevention"}]},"trialDetails":[{"nctId":"NCT06966635","phase":"PHASE4","title":"Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets","status":"RECRUITING","sponsor":"Huashan Hospital","startDate":"2024-04-10","conditions":"Hyperuricemia or Gout, Nephrolithiasis","enrollment":312},{"nctId":"NCT03745729","phase":"PHASE4","title":"Allopurinol in Acute Coronary Syndrome","status":"COMPLETED","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","startDate":"2019-03-01","conditions":"Acute Coronary Syndrome","enrollment":162}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"allopurinol sustained-release capsules","genericName":"allopurinol sustained-release capsules","companyName":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","companyId":"union-hospital-tongji-medical-college-huazhong-university-of-science-and-technol","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Allopurinol inhibits xanthine oxidase, the enzyme responsible for converting hypoxanthine and xanthine to uric acid, thereby reducing serum and urinary uric acid levels. Used for Gout prophylaxis and treatment, Hyperuricemia, Uric acid nephropathy prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}