{"id":"allocating-head-of-bed-position","safety":{"commonSideEffects":[{"rate":null,"effect":"Pressure ulcers (sacral/coccygeal region with prolonged elevation)"},{"rate":null,"effect":"Patient discomfort or reduced mobility"},{"rate":null,"effect":"Hemodynamic changes in critically ill patients"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Head-of-bed elevation is a non-pharmacological positioning intervention that leverages gravitational forces to prevent retrograde flow of gastric contents into the esophagus and upper airway. By maintaining the head and thorax at an incline (typically 30–45 degrees), this approach reduces the likelihood of aspiration events and reflux-related complications. It is commonly used as a supportive care measure in hospitalized patients, particularly those at high risk for aspiration pneumonia or gastroesophageal reflux disease (GERD).","oneSentence":"Elevating the head of the bed reduces gastric reflux and aspiration risk by using gravity to maintain gastric contents below the esophageal sphincter.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:00:39.276Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of aspiration pneumonia in hospitalized or mechanically ventilated patients"},{"name":"Management of gastroesophageal reflux disease (GERD) symptoms"}]},"trialDetails":[{"nctId":"NCT05073159","phase":"PHASE3","title":"Head-of-Bed Positioning in Large Artery Acute Ischemic Stroke","status":"UNKNOWN","sponsor":"National University of Singapore","startDate":"2020-02-11","conditions":"Acute Ischemic Stroke","enrollment":182}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Allocating head-of-bed position","genericName":"Allocating head-of-bed position","companyName":"National University of Singapore","companyId":"national-university-of-singapore","modality":"Biologic","firstApprovalDate":"","aiSummary":"Elevating the head of the bed reduces gastric reflux and aspiration risk by using gravity to maintain gastric contents below the esophageal sphincter. Used for Prevention of aspiration pneumonia in hospitalized or mechanically ventilated patients, Management of gastroesophageal reflux disease (GERD) symptoms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}