{"id":"allergovit-birch-pollen","safety":{"commonSideEffects":[{"rate":null,"effect":"Local oral/mucosal irritation or itching"},{"rate":null,"effect":"Mild systemic allergic reactions"},{"rate":null,"effect":"Throat irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This product contains standardized birch pollen allergen extract administered sublingually or subcutaneously to induce immune tolerance. Through repeated exposure at increasing doses, the therapy shifts the immune response from IgE-mediated hypersensitivity toward IgG-blocking antibodies and regulatory T cells, reducing allergic symptoms upon natural birch pollen exposure.","oneSentence":"Allergovit Birch pollen is an allergen immunotherapy that desensitizes the immune system to birch pollen allergens through gradual exposure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:21:01.938Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Birch pollen-induced allergic rhinitis and/or allergic asthma"}]},"trialDetails":[{"nctId":"NCT01431859","phase":"PHASE4","title":"Can we Help People With the Oral Allergy Syndrome Eat Fresh Fruit?","status":"UNKNOWN","sponsor":"Royal Sussex County Hospital","startDate":"2012-07","conditions":"Oral Allergy Syndrome","enrollment":40},{"nctId":"NCT00263627","phase":"PHASE3","title":"Safety and Efficacy of Specific Immunotherapy With an Aluminium Hydroxide-adsorbed Allergoid Preparation of Birch Pollen Allergens","status":"COMPLETED","sponsor":"Allergopharma GmbH & Co. KG","startDate":"2005-06","conditions":"Pollen Allergy","enrollment":253},{"nctId":"NCT01523158","phase":"NA","title":"Mechanisms of Allergen Immunotherapy","status":"TERMINATED","sponsor":"Royal Sussex County Hospital","startDate":"2012-04","conditions":"Allergic Rhinitis","enrollment":2}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Allergovit Birch pollen","genericName":"Allergovit Birch pollen","companyName":"Royal Sussex County Hospital","companyId":"royal-sussex-county-hospital","modality":"Biologic","firstApprovalDate":"","aiSummary":"Allergovit Birch pollen is a small molecule used to treat conditions such as Oral Allergy Syndrome, Allergic Rhinitis, and Pollen Allergy. The exact mechanism of action of Allergovit Birch pollen is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}