{"id":"allergovac-himenoptera","safety":{"commonSideEffects":["Local injection site reactions","Mild systemic allergic reactions","Pruritus"],"contraindications":["Severe uncontrolled asthma","Active malignancy","Severe immunodeficiency"]},"_chembl":null,"modality":"Biologic","_dailymed":null,"mechanism":{"target":"IgE-mediated immune response","explanation":"The product works by administering controlled doses of hymenoptera venom allergens to gradually desensitize the immune system. This process shifts the immune response from IgE-mediated allergic reactions toward IgG4 production and regulatory T-cell responses, reducing the severity of allergic reactions to insect stings.","oneSentence":"Allergen immunotherapy that induces immune tolerance to hymenoptera venom through gradual exposure to increasing doses of venom allergens."},"_scrapedAt":"2026-03-28T03:21:09.651Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779123519,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"Pharmalgen","brand":"Pharmalgen","company":"ALK-Abelló","rationale":"Established hymenoptera venom immunotherapy product"},{"name":"Venomil","brand":"Venomil","company":"HAL Allergy","rationale":"Venom immunotherapy for bee and wasp allergy"},{"name":"Alutard SQ","brand":"Alutard SQ","company":"ALK-Abelló","rationale":"Allergen immunotherapy platform including venom products"}],"description":"Allergovac himenoptera is an allergen immunotherapy product developed by Roxall Medicina España for the treatment of hymenoptera venom allergy. It is designed to desensitize patients with severe allergic reactions to stings from bees, wasps, and other stinging insects through gradual exposure to venom allergens.","indications":{"approved":[{"status":"investigational","condition":"Hymenoptera venom allergy","patientPopulation":"Adults and children with documented severe allergic reactions to bee or wasp stings"}]},"trialDetails":[{"nctId":"NCT04112797","phase":"","title":"Study to Evaluate the Safety of Treatment With A\"LLERGOVAC® HIMENÓPTEROS\" in Patients Sensitized to This Venom","status":"UNKNOWN","sponsor":"Roxall Medicina España S.A","startDate":"2019-05-23","conditions":"Allergy to Himenoptera Venom","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Allergovac himenoptera","genericName":"Allergovac himenoptera","companyName":"Roxall Medicina España S.A","companyId":"roxall-medicina-espa-a-s-a","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}