{"id":"allergen-immunotherapy-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (erythema, swelling, pruritus)"},{"rate":null,"effect":"Systemic allergic reactions"},{"rate":null,"effect":"Anaphylaxis"},{"rate":null,"effect":"Oral pruritus"}]},"_chembl":{"chemblId":"CHEMBL2108766","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The extract contains standardized allergen proteins that are administered in gradually increasing doses to shift the immune response from IgE-mediated (allergic) to IgG-mediated (tolerant) pathways. This process induces regulatory T cells and reduces mast cell and basophil reactivity to the allergen, thereby decreasing symptoms upon natural allergen exposure.","oneSentence":"Allergen immunotherapy extract desensitizes the immune system to specific allergens by gradually exposing patients to increasing doses, promoting immune tolerance and reducing allergic responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:00:45.459Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Allergic asthma"},{"name":"Atopic dermatitis"}]},"trialDetails":[{"nctId":"NCT07348302","phase":"PHASE3","title":"Efficacy and Safety of SLIT in Patients With Rhinitis/RC With/Without Mild-moderate Asthma, Due to Dpt and/or Df","status":"RECRUITING","sponsor":"Inmunotek S.L.","startDate":"2025-04-02","conditions":"Rhinitis, Rhinoconjunctivitis","enrollment":736},{"nctId":"NCT06448585","phase":"PHASE4","title":"Dietary Supplement 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