{"id":"all-licensed-antiretroviral-medications","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Nausea and gastrointestinal disturbance"},{"rate":"5-20","effect":"Headache"},{"rate":"5-15","effect":"Rash"},{"rate":"variable","effect":"Lipodystrophy (fat redistribution)"},{"rate":"1-5","effect":"Hepatotoxicity"},{"rate":"<1","effect":"Lactic acidosis (rare)"},{"rate":"5-15","effect":"Peripheral neuropathy"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Licensed antiretrovirals work through multiple mechanisms: reverse transcriptase inhibitors block viral RNA-to-DNA conversion, protease inhibitors prevent viral protein maturation, integrase inhibitors block viral DNA integration into the host genome, and entry inhibitors prevent viral attachment or fusion with CD4+ cells. These drugs are used in combination (antiretroviral therapy) to suppress HIV viral load and restore immune function.","oneSentence":"Antiretroviral medications inhibit HIV replication by targeting viral enzymes or blocking viral entry into CD4+ T cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:27:00.953Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HIV-1 infection (treatment and prevention)"},{"name":"AIDS (acquired immunodeficiency syndrome)"}]},"trialDetails":[{"nctId":"NCT00867048","phase":"PHASE4","title":"Strategic Timing of Antiretroviral Treatment","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2009-04-15","conditions":"HIV Infection","enrollment":4688}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"All licensed antiretroviral medications","genericName":"All licensed antiretroviral medications","companyName":"University of Minnesota","companyId":"university-of-minnesota","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Antiretroviral medications inhibit HIV replication by targeting viral enzymes or blocking viral entry into CD4+ T cells. Used for HIV-1 infection (treatment and prevention), AIDS (acquired immunodeficiency syndrome).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}