{"id":"alk-hdm-ait-12-du","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (erythema, swelling, pruritus)"},{"rate":null,"effect":"Systemic allergic reactions"},{"rate":null,"effect":"Itching or swelling of mouth/throat"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is an allergy immunotherapy product designed to induce immune tolerance to house dust mite allergens by gradually exposing patients to increasing doses of HDM extract. The therapy works by shifting the immune response from IgE-mediated (allergic) to IgG-mediated (protective) antibodies and promoting regulatory T cell responses, thereby reducing allergic symptoms upon natural allergen exposure.","oneSentence":"ALK HDM AIT 12 DU is an allergen immunotherapy (AIT) vaccine that desensitizes the immune system to house dust mite (HDM) allergens through repeated subcutaneous administration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:44:30.320Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"House dust mite allergic rhinitis and/or asthma"}]},"trialDetails":[{"nctId":"NCT01433523","phase":"PHASE3","title":"House Dust Mite Treatment of Asthma. The MITRA Trial House Dust Mite Treatment of Asthma","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2011-08","conditions":"Asthma","enrollment":834}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"ALK HDM AIT 12 DU","genericName":"ALK HDM AIT 12 DU","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ALK HDM AIT 12 DU is an intervention being studied in clinical trials for the treatment of asthma. It is a part of the ALK House Dust Mite Allergy Immunotherapy Tablet, which is being investigated for its efficacy in treating asthma.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}