{"id":"alexidine","rwe":[{"pmid":"41438036","year":"2025","title":"Alexidine is a TAZ-specific small-molecule inhibitor that suppresses breast cancer invasion and metastasis.","finding":"","journal":"iScience","studyType":"Clinical Study"},{"pmid":"41418346","year":"2026","title":"Mechanisms of NMDA receptor inhibition by chlorhexidine and alexidine.","finding":"","journal":"Biochemical and biophysical research communications","studyType":"Clinical Study"},{"pmid":"41250301","year":"2026","title":"Virucidal Effects of Contact Lens Disinfectants Against Enveloped and Nonenveloped Pathogenic Viruses Causing Conjunctivitis.","finding":"","journal":"Eye & contact lens","studyType":"Clinical Study"},{"pmid":"41166305","year":"2025","title":"A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential.","finding":"","journal":"Cell reports","studyType":"Clinical Study"},{"pmid":"41060575","year":"2025","title":"Antimicrobial potential of compounds from the MMV pandemic response box and COVID box against carbapenem-resistant Acinetobacter baumannii.","finding":"","journal":"Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]","studyType":"Clinical Study"}],"tags":[{"label":"alexidine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1","category":"target"},{"label":"PTPMT1","category":"gene"},{"label":"TLR9","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bisguadine","offLabel":[],"synonyms":["alexidine","bisguadine","bisguanidine","alexidine dihydrochloride"],"timeline":[],"aiSummary":"Bisguadine is a small molecule with the synonyms ALEXIDINA, ALEXIDINE, COMPOUND 904, and STERWIN 904. Its modality is classified as a small molecule.","brandName":"Bisguadine","ecosystem":[],"mechanism":{"target":"Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, Toll-like receptor 9, Beta-lactamase","targets":[{"gene":"PTPMT1","source":"DrugCentral","target":"Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1","protein":"Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"},{"gene":"TLR9","source":"DrugCentral","target":"Toll-like receptor 9","protein":"Toll-like receptor 9"}],"modality":"Small Molecule","drugClass":"alexidine","explanation":"Think of it like a key that unlocks a door. In this case, the key is Bisguadine, and the door is a cellular pathway that's locked by the phosphatase enzymes. By inhibiting these enzymes, Bisguadine can help unlock the pathway and allow the cell to function properly.","oneSentence":"Bisguadine works by inhibiting phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, which are enzymes involved in cellular signaling pathways.","technicalDetail":"Bisguadine exerts its effects by competitively inhibiting the phosphatase activity of phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1, thereby modulating the phosphorylation status of downstream targets and influencing various cellular processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/113","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ALEXIDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALEXIDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:36:03.768369","biosimilars":[],"competitors":[{"drugName":"hydroxychloroquine","drugSlug":"hydroxychloroquine","fdaApproval":"1955-04-18","genericCount":15,"patentStatus":"Off-patent — generic 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