{"id":"alendronate-aln","safety":{"commonSideEffects":[{"rate":"5–20","effect":"Gastrointestinal upset (nausea, dyspepsia, abdominal pain)"},{"rate":"0.1–1","effect":"Esophageal irritation / ulceration"},{"rate":"1–10","effect":"Musculoskeletal pain"},{"rate":"1–5","effect":"Headache"},{"rate":"<0.1","effect":"Osteonecrosis of the jaw (rare, high-dose/IV use)"},{"rate":"<0.1","effect":"Atypical femoral fractures (rare, long-term use)"}]},"_chembl":{"chemblId":"CHEMBL675","moleculeType":"Small molecule","molecularWeight":"271.08"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a bisphosphonate, alendronate is selectively taken up by osteoclasts during bone resorption. Once internalized, it inhibits farnesyl pyrophosphate synthase, disrupting the prenylation of small GTPases required for osteoclast function and survival. This leads to decreased bone turnover and increased bone mineral density, making it effective for conditions characterized by excessive bone loss.","oneSentence":"Alendronate inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite on the bone surface and blocking farnesyl pyrophosphate synthase in the mevalonate pathway.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:10.317Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoporosis in postmenopausal women"},{"name":"Osteoporosis in men"},{"name":"Glucocorticoid-induced osteoporosis"},{"name":"Paget's disease of bone"}]},"trialDetails":[{"nctId":"NCT07216794","phase":"PHASE2","title":"Small Trial of Alendronate Impact on the Reservoir of HIV","status":"NOT_YET_RECRUITING","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2026-01-17","conditions":"HIV","enrollment":30},{"nctId":"NCT05575167","phase":"","title":"Single or Repeat Zoledronate Versus Alendronate Following Denosumab (EUROpean Denosumab Effects Consolidation Study)","status":"RECRUITING","sponsor":"424 General Military Hospital","startDate":"2023-11-28","conditions":"Osteoporosis, Postmenopausal","enrollment":125},{"nctId":"NCT04177940","phase":"PHASE4","title":"Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2020-08-17","conditions":"Osteoporosis","enrollment":45},{"nctId":"NCT05527548","phase":"PHASE4","title":"A Single-blind RCT to Investigate the Effect of Alendronate on Knee Function Following ACLR","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2022-12-22","conditions":"ACL Reconstruction","enrollment":64},{"nctId":"NCT00896532","phase":"PHASE2","title":"Romosozumab (AMG 785) in Postmenopausal Women With Low Bone Mineral Density","status":"COMPLETED","sponsor":"Amgen","startDate":"2009-06-03","conditions":"Low Bone Mineral Density, Postmenopausal Osteoporosis","enrollment":419},{"nctId":"NCT04140006","phase":"PHASE1, PHASE2","title":"Efficacy of Antiresorptive and Bone Forming Material on Dental Implants","status":"UNKNOWN","sponsor":"University of Baghdad","startDate":"2019-07-01","conditions":"Partial Edentulism","enrollment":20},{"nctId":"NCT03204097","phase":"PHASE2, PHASE3","title":"Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontitis","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2016-03","conditions":"Chronic Periodontitis","enrollment":90},{"nctId":"NCT02516111","phase":"PHASE2, PHASE3","title":"Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2014-09","conditions":"Chronic Periodontitis","enrollment":120},{"nctId":"NCT02461667","phase":"PHASE2, PHASE3","title":"Alendronate Compared to Metformin in Chronic Periodontitis","status":"COMPLETED","sponsor":"Government Dental College and Research Institute, Bangalore","startDate":"2014-07","conditions":"Chronic Periodontitis","enrollment":108},{"nctId":"NCT00000400","phase":"PHASE2","title":"Alendronate and/or Parathyroid Hormone for Osteoporosis","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"1999-08","conditions":"Osteoporosis","enrollment":176},{"nctId":"NCT01535027","phase":"PHASE4","title":"Combined Administration of Teripapartide and Antiresorptive Agents in Postmenopausal Osteoporosis","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2006-03","conditions":"Osteoporosis","enrollment":125},{"nctId":"NCT00330460","phase":"PHASE3","title":"A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.","status":"COMPLETED","sponsor":"Amgen","startDate":"2006-05","conditions":"Osteoporosis, Osteopenia","enrollment":1189}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":631,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Alendronate (ALN)","genericName":"Alendronate (ALN)","companyName":"Chinese University of Hong Kong","companyId":"chinese-university-of-hong-kong","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alendronate is a medication used to treat conditions such as postmenopausal osteoporosis, low bone mineral density, and osteoporosis. It has also been studied for its potential use in chronic periodontitis, although the specific use of 1% Alendronate gel in combination with aloe vera gel is for treating furcation defects in chronic periodontitis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}