{"id":"albuterol-ipratropium-bromide","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nervousness"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Palpitations"}]},"_chembl":{"chemblId":"CHEMBL2134724","moleculeType":"Small molecule","molecularWeight":"430.38"},"_dailymed":{"setId":"2ebc820b-a423-46ef-8eba-9fbc93daff44","title":"IPRATROPIUM BROMIDE AND ALBUTEROL SULFATE SOLUTION [GOLDEN STATE MEDICAL SUPPLY, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Albuterol is a short-acting beta-2 agonist that increases cAMP in airway smooth muscle cells, causing bronchodilation. Ipratropium bromide is an anticholinergic agent that blocks M3 muscarinic receptors on airway smooth muscle, preventing acetylcholine-induced bronchoconstriction. Together, they provide complementary bronchodilation through independent pathways, making the combination more effective than either agent alone for acute airway obstruction.","oneSentence":"This combination bronchodilator relaxes airway smooth muscle through dual action: albuterol stimulates beta-2 adrenergic receptors while ipratropium blocks muscarinic acetylcholine receptors.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:20:49.093Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute bronchospasm and airway obstruction in pediatric patients"},{"name":"COPD exacerbation (pediatric)"},{"name":"Asthma exacerbation (pediatric)"}]},"trialDetails":[{"nctId":"NCT06785272","phase":"PHASE3","title":"Magnesium Trial in Acute Asthma in Emergency Department","status":"RECRUITING","sponsor":"Suzanne Schuh","startDate":"2025-10-08","conditions":"Asthma","enrollment":192},{"nctId":"NCT07112456","phase":"PHASE2","title":"Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations","status":"NOT_YET_RECRUITING","sponsor":"Oman Medical Speciality Board","startDate":"2026-09-01","conditions":"Asthma Acute, Asthma Attack, Asthma Exacerbations","enrollment":100},{"nctId":"NCT05667727","phase":"PHASE4","title":"The Effect of Nebulized Epinephrine in Asthma Exacerbation in Pediatric Age Group With the Standard Treatment Compared to Standard Treatment Using Improvement PRAM Score as a Primary Outcome","status":"COMPLETED","sponsor":"Oman Medical Speciality Board","startDate":"2023-10-15","conditions":"Shortness of Breath, Asthma in Children, Epinephrine Causing Adverse Effects in Therapeutic Use","enrollment":30},{"nctId":"NCT05786950","phase":"NA","title":"Neural Respiratory Drive of Patients With Chronic Obstructive Pulmonary Disease","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Guangzhou Medical University","startDate":"2023-01-01","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":44},{"nctId":"NCT06918418","phase":"PHASE4","title":"A Comparative Study of Adding Ipratropium to Salbutamol for the Treatment of Asthma Attack in Children","status":"COMPLETED","sponsor":"Children's Hospital and Institute of Child Health, Multan","startDate":"2024-01-01","conditions":"Asthma Exacerbation, Children","enrollment":60},{"nctId":"NCT06825013","phase":"PHASE4","title":"Bronchodilators and Lung Mechanics During Exercise in COPD","status":"RECRUITING","sponsor":"Dr. J. 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