{"id":"albendazole-plus-praziquantel","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL976","moleculeType":"Small molecule","molecularWeight":"312.41"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Albendazole inhibits β-tubulin polymerization in parasitic nematodes and cestodes, preventing microtubule assembly and causing energy depletion. Praziquantel increases cell membrane permeability to calcium in trematodes and cestodes, leading to paralysis and detachment from host tissues. The combination provides broad-spectrum coverage against multiple helminth species.","oneSentence":"Albendazole and praziquantel are antihelmintic agents that disrupt microtubule formation and parasite motility, causing paralysis and death of various parasitic worms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:20:42.075Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Soil-transmitted helminthiasis (hookworm, roundworm, whipworm)"},{"name":"Schistosomiasis"},{"name":"Taeniasis (tapeworm infection)"},{"name":"Polyparasitic infections in endemic regions"}]},"trialDetails":[{"nctId":"NCT07074444","phase":"PHASE4","title":"Treatment of Clonorchiasis in Guangxi With Albendazole, Tribendimidine, and Praziquantel","status":"RECRUITING","sponsor":"First Affiliated Hospital of Guangxi Medical University","startDate":"2025-07-22","conditions":"Clonorchiasis","enrollment":318},{"nctId":"NCT05323396","phase":"NA","title":"HIV And Parasitic Infection (HAPI) Study","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2022-05-02","conditions":"HIV Coinfection","enrollment":120},{"nctId":"NCT06565507","phase":"PHASE2, PHASE3","title":"Oxfendazole in Mild Parenchymal Brain Cysticercosis","status":"NOT_YET_RECRUITING","sponsor":"Universidad Peruana Cayetano Heredia","startDate":"2024-12-15","conditions":"Brain Cysticercosis","enrollment":544},{"nctId":"NCT06376396","phase":"PHASE4","title":"Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis","status":"NOT_YET_RECRUITING","sponsor":"R-Evolution Worldwide S.r.l. Impresa Sociale","startDate":"2024-06","conditions":"Neurocysticercosis","enrollment":300},{"nctId":"NCT06182176","phase":"NA","title":"Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2024-05-27","conditions":"Malaria, Soil Transmitted Helminths, Schistosomiasis","enrollment":1200},{"nctId":"NCT02947581","phase":"PHASE3","title":"Sub Arachnoid Neurocysticercosis Treatment Outcome (SANTO)","status":"TERMINATED","sponsor":"Universidad Peruana Cayetano Heredia","startDate":"2016-11-14","conditions":"Neurocysticercosis","enrollment":107},{"nctId":"NCT05354258","phase":"NA","title":"Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children","status":"UNKNOWN","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2022-06-16","conditions":"Malaria, Soil Transmitted Helminths, Schistosomiasis","enrollment":600},{"nctId":"NCT02366884","phase":"PHASE2","title":"Clinical Evaluation of a New Form of Cancer Therapy (Atavistic Chemotherapy) Based on the Principles of Atavistic Metamorphosis (2011)","status":"UNKNOWN","sponsor":"Dr. Frank Arguello Cancer Clinic","startDate":"2011-07-26","conditions":"Neoplasms","enrollment":250},{"nctId":"NCT00441285","phase":"PHASE2, PHASE3","title":"Neurocysticercosis: Combined Treatment With Praziquantel (PZQ) and Albendazole (ABZ)","status":"COMPLETED","sponsor":"Universidad Peruana Cayetano Heredia","startDate":"2010-01","conditions":"Neurocysticercosis, Epilepsy","enrollment":156},{"nctId":"NCT01722539","phase":"PHASE3","title":"Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyrimethamine Plus Piperaquine in Schoolchildren","status":"COMPLETED","sponsor":"Universiteit Antwerpen","startDate":"2012-11","conditions":"Healthy","enrollment":616},{"nctId":"NCT01541631","phase":"NA","title":"A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes","status":"UNKNOWN","sponsor":"Catholic University of Health and Allied Sciences","startDate":"2012-05","conditions":"Anemia, Intestinal Helminthiasis, Intestinal Schistosomiasis","enrollment":2000},{"nctId":"NCT01459146","phase":"PHASE4","title":"Artemisinin-based Combination Therapy-Intermittent Preventive Treatment (ACT-IPT) Trial Among Schoolchildren in Kassena-Nankana, Ghana","status":"UNKNOWN","sponsor":"Navrongo Health Research Centre, Ghana","startDate":"2010-12","conditions":"Malaria, Schistosomiasis, Helminthiasis","enrollment":345},{"nctId":"NCT00817713","phase":"NA","title":"Can Presumptive Anthelminthic Treatment Delay the Progression of HIV in ART-naïve Patients in Rural Africa?","status":"TERMINATED","sponsor":"Swiss Tropical & Public Health Institute","startDate":"2009-01","conditions":"HIV Infections, Helminthiasis","enrollment":295}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":36,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Albendazole plus Praziquantel","genericName":"Albendazole plus Praziquantel","companyName":"Navrongo Health Research Centre, Ghana","companyId":"navrongo-health-research-centre-ghana","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Albendazole and praziquantel are antihelmintic agents that disrupt microtubule formation and parasite motility, causing paralysis and death of various parasitic worms. Used for Soil-transmitted helminthiasis (hookworm, roundworm, whipworm), Schistosomiasis, Taeniasis (tapeworm infection).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}