{"id":"alatrofloxacin","rwe":[{"pmid":"30000435","year":"2006","title":"Alatrofloxacin.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"34055238","year":"2021","title":"Prediction of repurposed drugs for Coronaviruses using artificial intelligence and machine learning.","finding":"","journal":"Computational and structural biotechnology journal","studyType":"Clinical Study"},{"pmid":"20655887","year":"2010","title":"Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction.","finding":"","journal":"Chemico-biological interactions","studyType":"Clinical Study"},{"pmid":"17961195","year":"2008","title":"Knowledge creation about ADRs--turning the perspective from the rear mirror to the projector?","finding":"","journal":"British journal of clinical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"alatrofloxacin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Acute Moraxella catarrhalis bronchitis","category":"indication"},{"label":"Acute bacterial bronchitis","category":"indication"},{"label":"Acute bacterial sinusitis","category":"indication"},{"label":"Acute gonococcal cervicitis","category":"indication"},{"label":"Acute gonococcal endometritis","category":"indication"},{"label":"Acute gonococcal urethritis","category":"indication"},{"label":"Pfizer","category":"company"},{"label":"Approved 1990s","category":"decade"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Topoisomerase II Inhibitors","category":"pharmacology"},{"label":"Topoisomerase Inhibitors","category":"pharmacology"}],"phase":"marketed","safety":{"drugInteractions":[{"url":"/drug/mesoridazine","drug":"mesoridazine","action":"Avoid combination","effect":"May interact with Alatrofloxacin Mesylate, Mesoridazine","source":"DrugCentral","drugSlug":"mesoridazine"},{"url":"/drug/thioridazine","drug":"thioridazine","action":"Avoid combination","effect":"May interact with Alatrofloxacin Mesylate, Thioridazine","source":"DrugCentral","drugSlug":"thioridazine"}],"commonSideEffects":[]},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=ALATROFLOXACIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:14:38.420465+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:14:43.750553+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALATROFLOXACIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:14:44.021754+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Bacterial DNA gyrase inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:14:45.079867+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200498/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:14:44.719434+00:00"}},"allNames":["alatrofloxacin mesilate","alatrofloxacin mesylate","alatrofloxacin"],"offLabel":[],"synonyms":["alatrofloxacin mesilate","alatrofloxacin mesylate","alatrofloxacin"],"timeline":[{"date":"1997-12-18","type":"positive","source":"DrugCentral","milestone":"FDA approval (Pfizer)"}],"aiSummary":"Alatrofloxacin is a small molecule antibiotic developed by Pfizer, which is currently owned by the same company. 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