{"id":"alanyl-glutamine","rwe":[{"pmid":"41483516","year":"2026","title":"Tetracycline-induced alterations of gut microbiota and metabolism exacerbate imidacloprid susceptibility in honey bees (Apis mellifera).","finding":"","journal":"Journal of hazardous materials","studyType":"Clinical Study"},{"pmid":"41424695","year":"2025","title":"Alanyl-Glutamine Attenuates Soybean Meal-Induced Intestinal Dysfunction and Growth Retardation in Largemouth Bass (Micropterus salmoides).","finding":"","journal":"Aquaculture nutrition","studyType":"Clinical Study"},{"pmid":"41033017","year":"2026","title":"Enhanced synthesis of alanyl-glutamine dipeptide via molecular modification and process optimization of α-amino acid ester acyltransferase EAET.","finding":"","journal":"Enzyme and microbial technology","studyType":"Clinical Study"},{"pmid":"40996178","year":"2025","title":"Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients.","finding":"","journal":"Pakistan journal of pharmaceutical sciences","studyType":"Clinical Study"},{"pmid":"40419899","year":"2025","title":"Benefits of alanyl-glutamine and omega-3 PUDAs in postoperative gastroduodenal perforation patients: A single-center retrospective study.","finding":"","journal":"Medicine","studyType":"Clinical Study"}],"tags":[{"label":"alanyl glutamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B05XB02","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_3","safety":{"commonSideEffects":[{"effect":"Nausea","drugRate":"5.6%","placeboRate":"","totalAtRisk":18,"totalAffected":1,"trialsReporting":1},{"effect":"Elevated AST levels","drugRate":"5.6%","placeboRate":"","totalAtRisk":18,"totalAffected":1,"trialsReporting":1},{"effect":"Elevated CPK levels","drugRate":"5.6%","placeboRate":"","totalAtRisk":18,"totalAffected":1,"trialsReporting":1},{"effect":"Elevated temperature","drugRate":"0.0%","placeboRate":"","totalAtRisk":18,"totalAffected":0,"trialsReporting":1}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dipeptamin","offLabel":[],"synonyms":["alanyl glutamine","alanyl-glutamine","dipeptamin","L-Ala-L-Gln","L-Alanyl-L-glutamine"],"timeline":[],"brandName":"Dipeptamin","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"alanyl glutamine","explanation":"Think of Dipeptamin like a puzzle piece that helps the body build and repair tissues, such as muscles and organs. It does this by providing the raw materials that the body needs to create new proteins. This can be especially important for people who are recovering from illness or injury.","oneSentence":"Dipeptamin works by providing the body with a building block of protein, specifically the amino acids alanine and glutamine.","technicalDetail":"Dipeptamin is a dipeptide composed of alanine and glutamine, which are both essential amino acids. It is thought to work by increasing the levels of these amino acids in the body, where they can be used to build and repair tissues."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4319","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=ALANYL%20GLUTAMINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=ALANYL GLUTAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:31:31.396918","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:41:35.212164+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"arginine","drugSlug":"arginine","fdaApproval":"1973-02-28","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"lysine","drugSlug":"lysine","fdaApproval":"","relationship":"same-class"}],"genericName":"alanyl glutamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"arginine","brandName":"arginine","genericName":"arginine","approvalYear":"1973","relationship":"same-class"},{"drugId":"lysine","brandName":"lysine","genericName":"lysine","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03967795","phase":"NA","title":"Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Besancon","startDate":"2019-11-28","conditions":["Enteral Nutrition","Intensive Care Unit","Biomarkers"],"enrollment":73,"completionDate":"2023-04-24"},{"nctId":"NCT04305769","phase":"PHASE2","title":"Alanyl-glutamine Supplementation for C. 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Group","startDate":"2003-10","conditions":["ICU Patients"],"enrollment":1000,"completionDate":"2009-08"},{"nctId":"NCT00133562","phase":"PHASE3","title":"HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition","status":"WITHDRAWN","sponsor":"University of Virginia","startDate":"2004-08","conditions":["Diarrhea, Malnutrition","Other Nutritional Deficiencies"],"enrollment":108,"completionDate":"2006-05"},{"nctId":"NCT00338221","phase":"PHASE3","title":"Clinical Trial of Alanyl-Glutamine or Glycine in Children With Persistent Diarrhea or Malnutrition","status":"WITHDRAWN","sponsor":"University of Virginia","startDate":"2004-08","conditions":["Diarrhea, Malnutrition"],"enrollment":108,"completionDate":"2005-04"},{"nctId":"NCT00732849","phase":"PHASE4","title":"The Impact of the Type and Route of Nutritional Support on Infectious Complications After Upper Gastrointestinal Surgery","status":"COMPLETED","sponsor":"Jagiellonian University","startDate":"2002-06","conditions":["Gastrointestinal Surgery"],"enrollment":600,"completionDate":"2007-11"},{"nctId":"NCT00558155","phase":"PHASE4","title":"The Impact of Immunostimulating Nutrition on the Outcome of Surgery","status":"COMPLETED","sponsor":"Jagiellonian University","startDate":"2001-06","conditions":["Gastric Cancer","Pancreatic Cancer"],"enrollment":214,"completionDate":"2005-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010080","UNII":"U5JDO2770Z","CHEBI":"CHEBI:73788","RXNORM":"1359422","UMLSCUI":"C0051080","ChEMBL_ID":"CHEMBL3707366","DRUGBANK_ID":"DB11876","PUBCHEM_CID":"123935","SNOMEDCT_US":"422393000","MESH_SUPPLEMENTAL_RECORD_UI":"C054122"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":236,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"B05XB02","allCodes":["B05XB02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 15","pmid":"41483516","title":"Tetracycline-induced alterations of gut microbiota and metabolism exacerbate imidacloprid susceptibility in honey bees (Apis mellifera).","journal":"Journal of hazardous materials"},{"date":"2025","pmid":"41424695","title":"Alanyl-Glutamine Attenuates Soybean Meal-Induced Intestinal Dysfunction and Growth Retardation in Largemouth Bass (Micropterus salmoides).","journal":"Aquaculture nutrition"},{"date":"2026 Jan","pmid":"41033017","title":"Enhanced synthesis of alanyl-glutamine dipeptide via molecular modification and process optimization of α-amino acid ester acyltransferase EAET.","journal":"Enzyme and microbial technology"},{"date":"2025 Sep-Oct","pmid":"40996178","title":"Effects of Ala-Gln dipeptide parenteral nutrition on rehabilitation and infection of liver transplantation patients.","journal":"Pakistan journal of pharmaceutical sciences"},{"date":"2025 May 23","pmid":"40419899","title":"Benefits of alanyl-glutamine and omega-3 PUDAs in postoperative gastroduodenal perforation patients: A single-center retrospective study.","journal":"Medicine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dipeptamin, also known as Alanyl Glutamine, is a small molecule drug in the alanyl glutamine class. Its mechanism of action and target are unknown, and it has not been approved by the FDA for any indications. The commercial status of Dipeptamin is unclear, and it is not known whether it is patented or available as a generic. Further research is needed to determine its safety and efficacy. As a result, Dipeptamin is not currently available for clinical use.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":10,"withResults":2},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-20T08:41:35.212164+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":true,"score":3}}