{"id":"al003","safety":{"commonSideEffects":[{"rate":null,"effect":"Amyloid-related imaging abnormalities (ARIA)"},{"rate":null,"effect":"Infusion reactions"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":{"setId":"614301bd-f735-5ede-e053-2991aa0ae3be","title":"AL0038400 ALBA BOTANICA FAST FIX SUN SPF30 (OCTOCRYLENE, OCTYL SALICYLATE, ZINC OXIDE) STICK [THE HAIN CELESTIAL GROUP, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AL003 binds to TREM2 (triggering receptor expressed on myeloid cells 2) on microglial cells, enhancing their phagocytic capacity and shifting them toward a neuroprotective phenotype. This activation promotes clearance of amyloid-beta and tau pathology while reducing neuroinflammation, potentially slowing neurodegeneration in Alzheimer's disease and other neurodegenerative conditions.","oneSentence":"AL003 is a monoclonal antibody that activates TREM2 signaling on microglia to promote neuroinflammatory resolution and clearance of pathogenic proteins in the central nervous system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T05:51:52.174Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Alzheimer's disease"}]},"trialDetails":[{"nctId":"NCT03822208","phase":"PHASE1","title":"First in Human Study for Safety and Tolerability of AL003.","status":"COMPLETED","sponsor":"Alector Inc.","startDate":"2019-03-29","conditions":"Healthy, Alzheimer Disease","enrollment":54}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"AL003","genericName":"AL003","companyName":"Alector Inc.","companyId":"alector-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"AL003 is a monoclonal antibody that activates TREM2 signaling on microglia to promote neuroinflammatory resolution and clearance of pathogenic proteins in the central nervous system. Used for Alzheimer's disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}