{"id":"al-coartem","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"5-15","effect":"Fever"},{"rate":"5-10","effect":"Nausea"},{"rate":"3-8","effect":"Vomiting"},{"rate":"3-8","effect":"Diarrhea"},{"rate":"3-8","effect":"Abdominal pain"},{"rate":"2-5","effect":"Dizziness"},{"rate":"rare","effect":"QT prolongation"}]},"_chembl":{"chemblId":"CHEMBL3961932","moleculeType":"Small molecule","molecularWeight":"423.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artemether, a semi-synthetic artemisinin derivative, rapidly reduces parasite biomass by generating reactive oxygen species that damage parasite membranes and proteins. Lumefantrine, a long-acting aminoalcohol, inhibits parasite heme polymerization and provides sustained suppression of remaining parasites. Together they provide rapid symptom relief and complete parasite clearance with reduced recrudescence risk.","oneSentence":"Coartem (artemether-lumefantrine) is a fixed-dose combination antimalarial that kills malaria parasites through artemether's rapid parasite clearance and lumefantrine's sustained blood schizonticide activity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:20:39.407Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi"}]},"trialDetails":[{"nctId":"NCT05343312","phase":"PHASE4","title":"In Vivo Efficacy of Artemether-Lumefantrine, Amodiaquine-Artesunate, Dihydroartemisinin-Piperaquine, and Pironaridine-Artesunate in Mozambique","status":"COMPLETED","sponsor":"Centro de Investigacao em Saude de Manhica","startDate":"2022-03-16","conditions":"Malaria","enrollment":870},{"nctId":"NCT06970600","phase":"NA","title":"Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique","status":"COMPLETED","sponsor":"Centro de Investigacao em Saude de Manhica","startDate":"2024-03-07","conditions":"Malaria (Uncomplicated)","enrollment":352},{"nctId":"NCT03453840","phase":"PHASE4","title":"Extended Duration Artemether-lumefantrine Treatment for Malaria in Children","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2018-02-21","conditions":"Uncomplicated Plasmodium Falciparum Malaria","enrollment":305},{"nctId":"NCT06347471","phase":"PHASE4","title":"The Transmission of Artemisinin Resistant Parasites Before and After Conventional Artemisinin-combination Therapy","status":"RECRUITING","sponsor":"Infectious Diseases Research Collaboration, Uganda","startDate":"2024-05-28","conditions":"Falciparum; Malaria","enrollment":120},{"nctId":"NCT05550909","phase":"PHASE2","title":"Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2022-10-17","conditions":"Malaria,Falciparum","enrollment":100},{"nctId":"NCT04280692","phase":"PHASE1, PHASE2","title":"Controlled Human Malaria Infection Transmission Model - Phase A","status":"SUSPENDED","sponsor":"University of Oxford","startDate":"2022-08-22","conditions":"Malaria,Falciparum","enrollment":44},{"nctId":"NCT06300970","phase":"PHASE4","title":"Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2022-08-09","conditions":"Plasmodium Falciparum, Malaria, Uncomplicated Malaria","enrollment":352},{"nctId":"NCT04695197","phase":"PHASE3","title":"Malaria as a Risk Factor for COVID-19 in Western Kenya and Burkina Faso","status":"COMPLETED","sponsor":"Liverpool School of Tropical Medicine","startDate":"2021-01-08","conditions":"Covid-19, Malaria","enrollment":143},{"nctId":"NCT05192265","phase":"PHASE2, PHASE3","title":"Efficacy and Safety of Pyronaridine-Artesunate Versus Artemether-Lumefantrine","status":"COMPLETED","sponsor":"University of Ibadan","startDate":"2019-05-20","conditions":"Malaria Fever, Plasmodium Falciparum Malaria, Uncomplicated Malaria","enrollment":172},{"nctId":"NCT00541385","phase":"PHASE3","title":"Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. 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