{"id":"akr-963","safety":{"commonSideEffects":[{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"AV conduction delays"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AKR-963 selectively activates adenosine A1 receptors, which are G-protein coupled receptors involved in immunoregulation and inflammation control. By engaging this pathway, the drug is designed to suppress excessive immune activation and reduce inflammatory signaling in disease states. This mechanism is being explored for conditions where immune modulation could provide therapeutic benefit.","oneSentence":"AKR-963 is a selective agonist of the adenosine A1 receptor that modulates immune and inflammatory responses.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:00:27.058Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and immune-mediated disorders (specific indication under investigation in Phase 3)"}]},"trialDetails":[{"nctId":"NCT01229566","phase":"PHASE3","title":"Efficacy Study to Treat Subjects With Severe Hypertriglyceridemia","status":"UNKNOWN","sponsor":"Trygg Pharma, Inc.","startDate":"2010-10","conditions":"Severe Hypertriglyceridemia","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"AKR-963","genericName":"AKR-963","companyName":"Trygg Pharma, Inc.","companyId":"trygg-pharma-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AKR-963 is a selective agonist of the adenosine A1 receptor that modulates immune and inflammatory responses. Used for Inflammatory and immune-mediated disorders (specific indication under investigation in Phase 3).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}