{"id":"ait-tablet","safety":{"commonSideEffects":[{"rate":"20-40","effect":"Oral pruritus"},{"rate":"10-30","effect":"Throat irritation"},{"rate":"5-15","effect":"Mouth edema"},{"rate":"5-15","effect":"Ear pruritus"},{"rate":"5-10","effect":"Gastrointestinal symptoms"}]},"_chembl":{"chemblId":"CHEMBL2146108","moleculeType":"Small molecule","molecularWeight":"365.39"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AIT (Allergen Immunotherapy) tablets work by delivering small, increasing doses of allergen extract under the tongue, which promotes immune tolerance through regulatory T cell induction and shift from Th2 to Th1/Treg responses. This sublingual route allows for local immune modulation in oral mucosa-associated lymphoid tissue, reducing allergic symptoms upon natural allergen exposure. The tablet formulation provides a convenient, non-injection alternative to traditional subcutaneous immunotherapy.","oneSentence":"AIT Tablet is an allergen immunotherapy tablet that desensitizes the immune system to specific allergens through gradual oral exposure.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:20:29.850Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis and/or allergic asthma caused by specific allergens (exact allergen depends on formulation)"}]},"trialDetails":[{"nctId":"NCT06448585","phase":"PHASE4","title":"Dietary Supplement (Beta-Glucans) in Allergic Patients Undergoing Subcutaneous Immunotherapy.","status":"COMPLETED","sponsor":"Gala Servicios Clinicos S.L.","startDate":"2024-05-29","conditions":"Rhinitis, Allergic Rhinoconjunctivitis, Rhinoconjunctivitis","enrollment":60},{"nctId":"NCT07013123","phase":"PHASE3","title":"Potency of HDM Sublingual AIT Tablets in Assuring the Persistency of Asthma Control in HDM Allergic Patients With Severe Asthma, Treated With Tezepelumab","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2025-07-15","conditions":"Severe Asthma, Allergy to House Dust Mites","enrollment":38},{"nctId":"NCT05119751","phase":"PHASE4","title":"Vestibular Versus Sublingual Route of AIT Tablets","status":"COMPLETED","sponsor":"Clinique Spécialisée en Allergies de la Capitale","startDate":"2021-10-25","conditions":"Hypersensitivity","enrollment":172},{"nctId":"NCT04100902","phase":"PHASE4","title":"The Effect of Allergen Immunotherapy on Anti-viral Immunity in Patients With Allergic Asthma","status":"COMPLETED","sponsor":"Bispebjerg Hospital","startDate":"2020-01-20","conditions":"Allergic Asthma Due to Dermatophagoides Pteronyssinus","enrollment":39},{"nctId":"NCT03746860","phase":"","title":"N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2018-05-09","conditions":"Allergic Rhinitis Due to House Dust Mite, Allergic Asthma Due to Dermatophagoides Farinae, Allergic Asthma Due to Dermatophagoides Pteronyssinus","enrollment":1508},{"nctId":"NCT04038268","phase":"","title":"Criteria Used by Health Professionals on the Selection of Allergen Immunotherapy in Real Clinical Practice","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2019-09-01","conditions":"Allergen Immunotherapy","enrollment":400},{"nctId":"NCT02005627","phase":"PHASE2","title":"Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2013-09-01","conditions":"Allergic Rhinitis","enrollment":46},{"nctId":"NCT01469182","phase":"PHASE3","title":"A Study of Ragweed (Ambrosia Artemisiifolia) Allergy Immunotherapy Tablet in Adults With Ragweed Allergies (P05751)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2011-11","conditions":"Allergy","enrollment":914},{"nctId":"NCT00978029","phase":"PHASE2","title":"Safety Study of Ragweed Allergy Immunotherapy Tablet in Subjects 50 Years of Age and Older (Study P06081)","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-11","conditions":"Rhinoconjunctivitis, Rhinitis, Conjunctivitis","enrollment":203},{"nctId":"NCT01433523","phase":"PHASE3","title":"House Dust Mite Treatment of Asthma. The MITRA Trial House Dust Mite Treatment of Asthma","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2011-08","conditions":"Asthma","enrollment":834},{"nctId":"NCT01454544","phase":"PHASE3","title":"A One Year Trial Evaluating the Safety and Efficacy of the ALK House Dust Mite Allergy Tablet","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2011-10","conditions":"House Dust Mite Allergy","enrollment":992},{"nctId":"NCT01675791","phase":"PHASE2","title":"A Dose-response Evaluation of ALK (the Sponsor) Tree Allergy Immunotherapy Tablet","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2012-08","conditions":"Birch Pollen Allergy","enrollment":637},{"nctId":"NCT01889875","phase":"NA","title":"Immunological Comparison of AIT and SCIT Immunotherapy Against Grass Pollen","status":"COMPLETED","sponsor":"Bispebjerg Hospital","startDate":"2010-11","conditions":"Allergic Rhinitis Due to Grass Pollens","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"AIT Tablet","genericName":"AIT Tablet","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Biologic","firstApprovalDate":"","aiSummary":"AIT Tablet is an allergen immunotherapy tablet that desensitizes the immune system to specific allergens through gradual oral exposure. Used for Allergic rhinitis and/or allergic asthma caused by specific allergens (e.g., grass pollen, tree pollen, dust mites, depending on formulation).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}